lymphocyte specific protein tyrosine kinase p56(lck)

Preferred Label : lymphocyte specific protein tyrosine kinase p56(lck);

MeSH definition : This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.;

MeSH synonym : c-lck, proto-oncogene protein; lck kinase; lck, proto-oncogene protein; protein c-lck, proto-oncogene; protein lck, proto-oncogene; proto oncogene protein c lck; proto oncogene protein lck; proto-oncogene protein c-lck; proto-oncogene protein lck; p56 lck; kinase, lck; protein tyrosine kinase p56(lck);

CISMeF synonym : EC 2.7.1.37;

Registry Number MeSH : EC 2.7.10.2;

Is substance : O;

UNII : EC 2.7.10.2;

Details

Origin ID

D019860;

UMLS CUI

C0065344;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Lck protooncogene, src family tyrosine kinase [OMIM gene]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Wee1-Like Protein Kinase [NCIt concept]
Indexing information
- 2,6-dimethylphenyl 2-((3,5-bis(methyloxy)-4-((3-(4-methyl-1-piperazinyl)propyl)oxy)phenyl)amino)-4-pyrimidinyl(2,4-bis(methyloxy)phenyl)carbamate [MeSH Supplementary Concept]
- 4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide [MeSH Supplementary Concept]
- 4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)phenyl)benzamide [MeSH Supplementary Concept]
- A 125800 [MeSH Supplementary Concept]
- stypoquinonic acid [MeSH Supplementary Concept]
Record concept(s)
- lymphocyte specific protein tyrosine kinase p56(lck) [MeSH concept]
Related MeSH Supplementary Concept(s)
- LCK protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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