GABA modulators

Preferred Label : GABA modulators;

MeSH definition : Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.;

MeSH synonym : modulators, gaba; gabaergic modulators; modulators, gabaergic; gamma-aminobutyric acid modulators; acid modulators, gamma-aminobutyric; modulators, gamma-aminobutyric acid; gamma aminobutyric acid modulators;

MeSH annotation : GEN or unspecified; prefer specifics; general or unspecified; prefer specifics;

Is substance : O;

action pharmacologique : O;

Details

Origin ID

D018757;

UMLS CUI

C0242976;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 2'-methoxy-6-methylflavone [MeSH Supplementary Concept]
- 4-amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide [MeSH Supplementary Concept]
- N-(bicyclo(2.2.1)hept-2-yl)-2-methyl-5-(4-(trifluoromethyl)phenyl)-4-pyrimidinamine [MeSH Supplementary Concept]
- dioxosarcoguaiacol [MeSH Supplementary Concept]
Record concept(s)
- GABA modulators [MeSH concept]
See also
- anesthetics, general [MeSH Descriptor]
- anti-anxiety agents [MeSH Descriptor]
- gaba plasma membrane transport proteins [MeSH Descriptor]
- hypnotics and sedatives [MeSH Descriptor]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- ASP8062 [MeSH Supplementary Concept]
- PF-06372865 [MeSH Supplementary Concept]
- SGE-102 [MeSH Supplementary Concept]
- SGE-872 [MeSH Supplementary Concept]
- alprazolam [MeSH Descriptor]
- amobarbital [MeSH Descriptor]
- amobarbital, secobarital drug combination [MeSH Supplementary Concept]
- barbital [MeSH Descriptor]
- brexanolone [MeSH Supplementary Concept]
- bromazepam [MeSH Descriptor]
- chlordiazepoxide [MeSH Descriptor]
- chlormethiazole [MeSH Descriptor]
- clonazepam [MeSH Descriptor]
- clorazepate dipotassium [MeSH Descriptor]
- diazepam [MeSH Descriptor]
- estazolam [MeSH Descriptor]
- flumazenil [MeSH Descriptor]
- flunitrazepam [MeSH Descriptor]
- flurazepam [MeSH Descriptor]
- ganaxolone [MeSH Supplementary Concept]
- hexobarbital [MeSH Descriptor]
- imidazenil [MeSH Supplementary Concept]
- indiplon [MeSH Supplementary Concept]
- lorazepam [MeSH Descriptor]
- medazepam [MeSH Descriptor]
- mephobarbital [MeSH Descriptor]
- midazolam [MeSH Descriptor]
- nimetazepam [MeSH Supplementary Concept]
- nitrazepam [MeSH Descriptor]
- nordazepam [MeSH Descriptor]
- oxazepam [MeSH Descriptor]
- pentobarbital [MeSH Descriptor]
- phenobarbital [MeSH Descriptor]
- phetharbital [MeSH Supplementary Concept]
- prazepam [MeSH Descriptor]
- primidone [MeSH Descriptor]
- pyrazolam [MeSH Supplementary Concept]
- secobarbital [MeSH Descriptor]
- temazepam [MeSH Descriptor]
- thiamylal [MeSH Descriptor]
- thiopental [MeSH Descriptor]
- triazolam [MeSH Descriptor]
- zaleplon [MeSH Supplementary Concept]
- zolazepam [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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