Preferred Label : Leukocyte Common Antigens;
MeSH definition : High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES
and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase
activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS.
The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing
and differential usage of three exons.; High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES
and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and
possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular
signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple
isoforms that result from alternative mRNA splicing and differential usage of three
exons.;
MeSH synonym : antigen, cd45; antigen, leukocyte common; antigens, l-ca; antigens, leukocyte common; antigens, t200; cd45 antigen; cd45 antigens; l ca antigens; l-ca antigens; leukocyte common antigen; protein tyrosine phosphatase, receptor type, c; t200 antigens; Antigens, CD45;
MeSH hyponym : CD45RA antigens; CD45RB antigens; CD45RCAntigens; B220 antigens; Antigens, CD45RB; Antigens, B220; CD45R Antigens; Antigens, CD45R; B220 Antigen; Antigen, B220; Antigens, CD45RA; 2H4 Antigens; Antigens, 2H4;
Related MeSH term : CD45RO antigens; Antigens, CD45RO; CD45R0 Antigens; Antigens, CD45R0;
Registry Number MeSH : EC 3.1.3.48;
Is substance : O;
UNII : EC 3.1.3.48;
Origin ID : D017493;
UMLS CUI : C0054961;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES
and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase
activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS.
The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing
and differential usage of three exons.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES
and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and
possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular
signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple
isoforms that result from alternative mRNA splicing and differential usage of three
exons.
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=169157
2011
France
scientific and technical information
severe combined immunodeficiency
severe combined immunodeficiency
Leukocyte Common Antigens
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