neurofilament proteins

Preferred Label : neurofilament proteins;

MeSH definition : Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302);

MeSH synonym : proteins, neurofilament; Neurofilament Protein; Protein, Neurofilament;

MeSH hyponym : neurofilament triplet proteins; heavy neurofilament protein; Proteins, Neurofilament Triplet; Triplet Proteins, Neurofilament; Neurofilament Protein, Heavy; Protein, Heavy Neurofilament;

MeSH annotation : /biosyn /physiol permitted;

Is substance : O;

Details

Origin ID

D016900;

UMLS CUI

C0085418;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Neurofilament Light Polypeptide [NCIt concept]
- Neurofilament Medium Polypeptide [NCIt concept]
- Neurofilament heavy chain [LOINC component]
Currated CISMeF NLP mapping
- Neurofilament protein [FMA entity]
- Neurofilament protein (substance) [SNOMED CT concept]
Record concept(s)
- heavy neurofilament protein [MeSH concept]
- neurofilament proteins [MeSH concept]
- neurofilament triplet proteins [MeSH concept]
Related MeSH Supplementary Concept(s)
- Inab protein, zebrafish [MeSH Supplementary Concept]
- NF-220 protein, loligo pealei [MeSH Supplementary Concept]
- NF-M13 protein, human [MeSH Supplementary Concept]
- NF-M17 protein, human [MeSH Supplementary Concept]
- NF70 protein, helix aspersa [MeSH Supplementary Concept]
- NFL-TBS.40-63 peptide [MeSH Supplementary Concept]
- neflb protein, zebrafish [MeSH Supplementary Concept]
- neurofilament protein 150 [MeSH Supplementary Concept]
- neurofilament protein H [MeSH Supplementary Concept]
- neurofilament protein L [MeSH Supplementary Concept]
- neurofilament protein M [MeSH Supplementary Concept]
- neurofilament protein NF 68 [MeSH Supplementary Concept]
- villin headpiece subdomain peptide [MeSH Supplementary Concept]
See also
- alzheimer disease [MeSH Descriptor]
- neurofibrillary tangles [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Neurofilament protein [FMA entity]
- Neurofilament protein (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients