Preferred Label : neurofibrillary tangles;
MeSH definition : Abnormal structures located in various parts of the brain and composed of dense arrays
of paired helical filaments (neurofilaments and microtubules). These double helical
stacks of transverse subunits are twisted into left-handed ribbon-like filaments that
likely incorporate the following proteins: (1) the intermediate filaments: medium-
and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins
map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER
DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm
in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon.
The number of these tangles, as seen in post mortem histology, correlates with the
degree of dementia during life. Some studies suggest that tangle antigens leak into
the systemic circulation both in the course of normal aging and in cases of Alzheimer
disease.;
MeSH synonym : neurofibrillary tangle; tangle, neurofibrillary; tangles, neurofibrillary;
MeSH annotation : one of the hallmarks of Alzheimer disease; A 11 qualif except /cytol; /genet permitted;
Wikipedia link : https://en.wikipedia.org/wiki/Neurofibrillary tangles;
Origin ID : D016874;
UMLS CUI : C0085400;
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
HPO term
Record concept(s)
See also
Semantic type(s)
UMLS correspondences (same concept)
Abnormal structures located in various parts of the brain and composed of dense arrays
of paired helical filaments (neurofilaments and microtubules). These double helical
stacks of transverse subunits are twisted into left-handed ribbon-like filaments that
likely incorporate the following proteins: (1) the intermediate filaments: medium-
and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins
map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER
DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm
in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon.
The number of these tangles, as seen in post mortem histology, correlates with the
degree of dementia during life. Some studies suggest that tangle antigens leak into
the systemic circulation both in the course of normal aging and in cases of Alzheimer
disease.