MeSH definition : External envelope protein of the human immunodeficiency virus which is encoded by
the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation
sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes
and monocytes/macrophages. Gp120 has been shown to interfere with the normal function
of CD4 and is at least partly responsible for the cytopathic effect of HIV.;
MeSH synonym : envelope glycoprotein gp120, hiv; env protein gp120, hiv; gp120 envelope glycoprotein, hiv; gp120, htlv-iii; hiv envelope glycoprotein gp120; htlv-iii gp120; htlv iii gp120; gp120(hiv);
External envelope protein of the human immunodeficiency virus which is encoded by
the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation
sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes
and monocytes/macrophages. Gp120 has been shown to interfere with the normal function
of CD4 and is at least partly responsible for the cytopathic effect of HIV.