MeSH definition : Products of the retroviral NEF GENE. They play a role as accessory proteins that influence
the rate of viral infectivity and the destruction of the host immune system. nef gene
products were originally found as factors that trans-suppress viral replication and
function as negative regulators of transcription. nef stands for negative factor.;
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence
the rate of viral infectivity and the destruction of the host immune system. nef gene
products were originally found as factors that trans-suppress viral replication and
function as negative regulators of transcription. nef stands for negative factor.