down-regulation

Preferred Label : down-regulation;

MeSH definition : A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.;

MeSH synonym : down-regulation (physiology); downregulation; down regulation;

MeSH hyponym : receptor Down-Regulation; Down-Regulation, Receptor;

MeSH annotation : DF: DOWN REG;

Wikipedia link : https://en.wikipedia.org/wiki/Downregulation;

Details

Origin ID

D015536;

UMLS CUI

C0013081;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Down-regulation, function (observable entity) [SNOMED CT concept]
- Receptor Down Regulation [NCIt concept]
- Regulating [ICNP action]
- Regulation [Terme SASMAG]
- Regulation [NCIt concept]
- Regulatory Process [NCIt concept]
- biological regulation [GO term]
- down-regulation [SNOMED Notion]
Record concept(s)
- Down-Regulation [MeSH concept]
- receptor Down-Regulation [MeSH concept]
See also
- feedback, physiological [MeSH Descriptor]
- up-regulation [MeSH Descriptor]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- Down-regulation, function (observable entity) [SNOMED CT concept]
- down-regulation [SNOMED Notion]
Validated automatic mappings to BTNT
- Receptor Down Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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