tryptophan hydroxylase

Preferred Label : tryptophan hydroxylase;

MeSH definition : An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.;

MeSH synonym : tryptophan monooxygenase; hydroxylase, tryptophan; monooxygenase, tryptophan;

MeSH CAS label : L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating);

Registry Number MeSH : EC 1.14.16.4;

Wikipedia link : https://en.wikipedia.org/wiki/Tryptophan hydroxylase;

Is substance : O;

UNII : EC 1.14.16.4;

Details

Origin ID

D014365;

UMLS CUI

C0041252;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Tryptophan 5-Hydroxylase 1 [NCIt concept]
Currated CISMeF NLP mapping
- Tryptophan 5-monooxygenase (substance) [SNOMED CT concept]
- tryptophan 5-monooxygenase [SNOMED Notion]
Indexing information
- 2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)-pyrimidin-4-yl)phenyl)propionic acid [MeSH Supplementary Concept]
- 3,4-dihydroxystyrene [MeSH Supplementary Concept]
- 4-chloroaniline [MeSH Supplementary Concept]
- AGN 2979 [MeSH Supplementary Concept]
- p-ethynylphenylalanine [MeSH Supplementary Concept]
Record concept(s)
- tryptophan hydroxylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- TPH1 protein, human [MeSH Supplementary Concept]
- TPH2 protein, human [MeSH Supplementary Concept]
- Tph1 protein, mouse [MeSH Supplementary Concept]
- Tph2 protein, mouse [MeSH Supplementary Concept]
- tph1 protein, rat [MeSH Supplementary Concept]
- tph2 protein, rat [MeSH Supplementary Concept]
- tph2 protein, zebrafish [MeSH Supplementary Concept]
See also
- tryptophan oxygenase [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Tryptophan 5-monooxygenase (substance) [SNOMED CT concept]
- tryptophan 5-monooxygenase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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