Preferred Label : tobramycin;

MeSH definition : An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.;

MeSH synonym : nebramycin factor 6;

MeSH hyponym : tobracin; nebcin; Tobramycin Sulfate; brulamycin; obracin; Sulfate, Tobramycin; Nebicin;

MeSH CAS label : D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy-;

MeSH Related Number : 32986-56-4 (Tobramycin); tobramycin sulfate; HJT0RXD7JK;

Registry Number MeSH : 32986-56-4;

Related CAS MeSH : HJT0RXD7JK (Tobramycin sulfate);

Wikipedia link : https://en.wikipedia.org/wiki/Tobramycin;

Codes EINECS : 251-322-5;

Is substance : O;

UNII : VZ8RRZ51VK;

InChIKey : NLVFBUXFDBBNBW-PBSUHMDJSA-N;

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An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

https://ansm.sante.fr/actualites/decision-dautorisation-dimportation-parallele-accordee-le-15-09-2022-tobi-300-mg-5-ml-solution-pour-inhalation-par-nebuliseur
2022
false
false
false
France
French
legislation
drug information
tobramycin
administration, inhalation
tobramycin

---
https://www.has-sante.fr/jcms/p_3399885/fr/tobramycine-medac-tobramycine-mucoviscidose
2022
false
false
false
France
administration, inhalation
treatment outcome
insurance, health, reimbursement
anti-bacterial agents
tobramycin
pseudomonas infections
pseudomonas aeruginosa
chronic disease
child
adolescent
adult
evaluation of the transparency committee
tobramycin
cystic fibrosis

---
https://www.has-sante.fr/jcms/p_3159950/fr/tobramycine-altan
2020
false
false
false
France
tobramycin
administration, inhalation
insurance, health, reimbursement
treatment outcome
child
adolescent
adult
pseudomonas infections
cystic fibrosis
chronic disease
anti-bacterial agents
evaluation of the transparency committee
tobramycin

---
https://pharmactuel.com/index.php/pharmactuel/article/view/1266
2020
false
false
false
Canada
drug substitution
drug resistance, bacterial
enterobacteriaceae infections
pseudomonas infections
pseudomonas aeruginosa
treatment outcome
journal article
gentamicins
tobramycin

---
https://www.has-sante.fr/jcms/p_3184671/fr/tobramycine-sun
2020
false
false
false
France
tobramycin
chronic disease
cystic fibrosis
pseudomonas infections
pseudomonas aeruginosa
Pneumonia Pseudomonas aeruginosa
child
adolescent
adult
administration, inhalation
anti-bacterial agents
treatment outcome
insurance, health, reimbursement
evaluation of the transparency committee
tobramycin

---
https://www.ema.europa.eu/en/medicines/human/EPAR/tobramycin-pari
2019
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
tobramycin
tobramycin
anti-bacterial agents
anti-bacterial agents
cystic fibrosis
child
adolescent
adult
chronic disease
Pneumonia pseudomonal
pseudomonas infections
pneumonia, bacterial
administration, inhalation
pseudomonas aeruginosa
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
tobramycin

---
http://ansm.sante.fr/S-informer/Informations-de-securite-Lettres-aux-professionnels-de-sante/Nebcine-solution-injectable-tobramycine-ne-pas-utiliser-par-voie-inhalee-Lettre-aux-professionnels-de-sante
2018
false
false
false
France
French
tobramycin
pharmacovigilance note
administration, inhalation
injections
tobramycin
Product containing tobramycin in parenteral dose form (medicinal product form)
anti-bacterial agents
drug hypersensitivity
anaphylaxis
bronchial spasm
inhalation exposure
sodium metabisulfite
pharmaceutic aids
Contraindications, Procedure
sulfites

---
http://www.has-sante.fr/portail/jcms/c_2588392/fr/tobi-tobi-podhaler
2016
false
France
French
evaluation of the transparency committee
adolescent
Long-term drug therapy (procedure)
antibiotic therapy
tobramycin
administration, inhalation
insurance, health, reimbursement
tobramycin
anti-bacterial agents
dry powder inhalers
multicenter studies as topic
tobramycin
anti-bacterial agents
clinical trials, phase iii as topic
adult
child
cystic fibrosis
pseudomonas aeruginosa
pseudomonas infections
chronic disease
pneumonia, bacterial

---
https://www.ema.europa.eu/medicines/human/EPAR/Vantobra
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
tobramycin
tobramycin
administration, inhalation
tobramycin
anti-bacterial agents
anti-bacterial agents
pneumonia, bacterial
pseudomonas aeruginosa
pseudomonas infections
Pneumonia Pseudomonas aeruginosa
child
adolescent
adult
chronic infectious disease
chronic disease
cystic fibrosis
Conventional release solution for nebulizer (dose form)
drug interactions
pregnancy
breast feeding
protein synthesis inhibitors
protein synthesis inhibitors
drug evaluation, preclinical
antibiotic therapy

---
http://www.has-sante.fr/portail/jcms/c_2038851/fr/tobramycine-mylan
2015
false
false
false
France
French
evaluation of the transparency committee
tobramycin
tobramycin

---
http://www.has-sante.fr/portail/jcms/c_1778248/fr/nebcine
http://www.has-sante.fr/portail/jcms/c_793451/nebcine
2014
false
France
French
Tobramycin Sulfate
Gram-Negative bacterial infections
drug therapy, combination
kidney infection
Genitourinary System Infection
sepsis
septicemia
endocarditis, bacterial
meningeal infection
staphylococcal skin infections
reproductive tract infections
respiratory tract infections
central nervous system infections
urinary tract infections
malignant staphylococcal infection of the face
Joint Infection
joint diseases
antibiotic therapy
tobramycin
anti-bacterial agents
injections
tobramycin
insurance, health, reimbursement
evaluation of the transparency committee

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60565723
2012
France
summary of product characteristics
capsules
metered dose inhalers
tobramycin

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61702541
2012
France
summary of product characteristics
package leaflet
tobramycin

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64078606
2012
France
summary of product characteristics
package leaflet
tobramycin

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69240211
2012
France
summary of product characteristics
package leaflet
ophthalmic solutions
tobramycin
eyedrops

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68200420
2012
France
summary of product characteristics
package leaflet
tobramycin
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68965192
2012
France
summary of product characteristics
package leaflet
tobramycin
injections

---
https://www.ema.europa.eu/medicines/human/EPAR/Tobi-Podhaler
2012
United Kingdom
English
French
summary of product characteristics
package leaflet
drug evaluation
syndication feed
antibiotic therapy
tobramycin
tobramycin
administration, inhalation
drug approval
treatment outcome
adult
child
adolescent
chronic disease
cystic fibrosis
pseudomonas aeruginosa
pseudomonas infections
anti-bacterial agents
anti-bacterial agents
pneumonia, bacterial
orphan drug production
dry powder inhalers
tobramycin
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical

---
http://www.has-sante.fr/portail/jcms/c_1230752/tobipodhaler-30112011-synthese-ct11466
http://www.has-sante.fr/portail/jcms/c_1173249/tobi-podhaler-30-11-2011-avis-ct11466
http://www.has-sante.fr/portail/jcms/c_1230794/tobi-podhaler-tobramycine-aminoside-par-voie-inhalee-synthese-d-avis
2011
France
French
antibiotic therapy
tobramycin
tobramycin
administration, inhalation
anti-bacterial agents
anti-bacterial agents
dry powder inhalers
orphan drug production
tobramycin
insurance, health, reimbursement
pseudomonas aeruginosa
pseudomonas infections
adult
adolescent
child
cystic fibrosis
chronic disease
treatment outcome
aged
clinical trials, phase iii as topic
multicenter studies as topic
pneumonia, bacterial
comparative study
guidelines for drug use
evaluation of the transparency committee

---
http://www.has-sante.fr/portail/jcms/c_1172458/tobi-podhaler
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-01/tobi_podhaler_30-11-2011_avis_ct11466.pdf
2011
France
French
evaluation of the transparency committee
antibiotic therapy
tobramycin
administration, inhalation
insurance, health, reimbursement
tobramycin
anti-bacterial agents
dry powder inhalers
multicenter studies as topic
tobramycin
anti-bacterial agents
clinical trials, phase iii as topic
adult
child
cystic fibrosis
pseudomonas aeruginosa
pseudomonas infections
chronic disease
pneumonia, bacterial

---
http://www.has-sante.fr/portail/display.jsp?id=c_490335
http://www.has-sante.fr/portail/jcms/c_1036518/tobradex
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-04/tobradex_-_ct_-_9446.pdf
2011
France
French
Adrenocortical steroid therapy
Glucocorticoid therapy
corticosteroid therapy
ophthalmic solutions
drug combinations
tobramycin
anti-bacterial agents
dexamethasone
anti-inflammatory agents
glucocorticoids
dexamethasone and antiinfectives
insurance, health, reimbursement
evaluation of the transparency committee

---
http://www.has-sante.fr/portail/display.jsp?id=c_456616
http://www.has-sante.fr/portail/jcms/c_1106856/tobrex
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-10/tobrex_05-10-2011_avis_11124.pdf
http://www.has-sante.fr/portail/jcms/c_400254/tobrex-lp-3-mg/ml-collyre-en-solution-flacon-de-5-ml-code-cip-366-634-3
2011
France
French
antibiotic therapy
tobramycin
anti-bacterial agents
ointments
ophthalmic solutions
tobramycin
insurance, health, reimbursement
eye infections, bacterial
administration, ophthalmic
evaluation of the transparency committee

---
http://www.lecrat.eu/?s=Tobramycine
2011
France
French
antibiotic therapy
tobramycin
pregnancy
anti-bacterial agents
tobramycin
drug information

---
http://www.meddispar.fr/index.php/medicaments/3657232
2009
France
French
tobramycin
nebulizers and vaporizers
administration, inhalation
pharmaceutical solutions
drug prescriptions
legislation, drug
tobramycin
drug information

---
http://www.has-sante.fr/portail/display.jsp?id=c_644334
http://www.has-sante.fr/portail/display.jsp?id=c_644339
2008
France
French
antibiotic therapy
tobramycin
anti-bacterial agents
pseudomonas aeruginosa
pseudomonas infections
cystic fibrosis
tobramycin
administration, inhalation
guidelines for drug use

---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Aminoglycosides-Amikacin-Gentamicin-and-Tobramycin.aspx
2008
Canada
popular works
drug information
tobramycin
gentamicins
amikacin
child

---
http://www.meddispar.fr/medicaments/3657232
2008
France
French
administration, inhalation
tobramycin
nebulizers and vaporizers
legislation, drug
drug prescriptions
tobramycin
drug information

---
http://www.has-sante.fr/portail/display.jsp?id=c_398766
2006
France
French
osteitis
bone substitutes
tobramycin
health technology assessment

---
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26/04/2025


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