Tobramycin - CISMeF

Preferred Label : Tobramycin;

NCIt synonyms : Tobramycin Base;

NCIt definition : An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.;

UNII : VZ8RRZ51VK;

InChIKey : NLVFBUXFDBBNBW-PBSUHMDJSA-N;

CAS number : 32986-56-4;

Chemical formula : C18H37N5O9;

ChEBI ID : CHEBI:28864;

Codes from synonyms : NSC0180514;

Details

Origin ID

C62082;

UMLS CUI

C0040341;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tobramycin (medicinal product) [SNOMED CT concept]
- Tobramycin [ICD-11 Extension code]
- Tobramycin [LOINC component]
- Tobramycin (substance) [SNOMED CT concept]
- tobramycin [ATC Code]
- tobramycin [ATC Code]
- tobramycin [Substance BNPC]
- tobramycin [SNOMED Notion]
- tobramycin [MeSH Descriptor]
- tobramycin [MeSH concept]
Validated automatic mappings to BTNT
- tobramycin [ATC Code]
- tobramycin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Tobramycin Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Tobramycin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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