thiotepa - CISMeF

Preferred Label : thiotepa;

MeSH definition : A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).;

MeSH synonym : tris(1-aziridinyl)phosphine sulfide; triethylenethiophosphoramide; thio-tepa; thio tepa; thiophosphamide;

MeSH hyponym : tespamin; NSC-6396; AI3-24916; girostan; tespa; NSC 6396; NSC6396; AI3 24916; AI324916;

MeSH CAS label : aziridine, 1,1',1''-phosphinothioylidynetris-;

MeSH Related Number : 52-24-4 (Thiotepa);

Registry Number MeSH : 52-24-4;

Wikipedia link : https://en.wikipedia.org/wiki/Thiotepa;

Codes EINECS : 200-135-7;

Is substance : O;

UNII : 905Z5W3GKH;

InChIKey : FOCVUCIESVLUNU-UHFFFAOYSA-N;

Details

Origin ID

D013852;

UMLS CUI

C0039871;

ATC code(s)
- thiotepa [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- thiotepa [Substance BNPC]
Pharmacological action(s)
- antineoplastic agents, alkylating [MeSH Descriptor]
- myeloablative agonists [MeSH Descriptor]
Record concept(s)
- AI3-24916 [MeSH concept]
- NSC-6396 [MeSH concept]
- girostan [MeSH concept]
- tespa [MeSH concept]
- tespamin [MeSH concept]
- thiotepa [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1-oxyl-2,2,6,6-tetramethyl-4-piperidyl-N,N,N',N'-bis(ethylene)phosphorodiamidothioate [MeSH Supplementary Concept]
- AVTMF protocol [MeSH Supplementary Concept]
- CTCb regimen [MeSH Supplementary Concept]
- D-CECaT regimen [MeSH Supplementary Concept]
- MATILDE regimen [MeSH Supplementary Concept]
- MITT protocol [MeSH Supplementary Concept]
- MTV protocol [MeSH Supplementary Concept]
- MVT protocol [MeSH Supplementary Concept]
- MiCaT protocol [MeSH Supplementary Concept]
- STAMP V regimen [MeSH Supplementary Concept]
- T-NOP protocol [MeSH Supplementary Concept]
- TAVE protocol [MeSH Supplementary Concept]
- TAVH protocol [MeSH Supplementary Concept]
- TBV protocol [MeSH Supplementary Concept]
- TMF protocol [MeSH Supplementary Concept]
- TMJ protocol [MeSH Supplementary Concept]
- TMM protocol [MeSH Supplementary Concept]
- TNT protocol [MeSH Supplementary Concept]
- TVTG protocol [MeSH Supplementary Concept]
- VTMF protocol [MeSH Supplementary Concept]
- VTMFAP protocol [MeSH Supplementary Concept]
- VTMFP protocol [MeSH Supplementary Concept]
- thiotepa-glutathione conjugate [MeSH Supplementary Concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing thiotepa (medicinal product) [SNOMED CT concept]
- Thiotepa [ICD-11 Extension code]
- Thiotepa [NCIt concept]
- Thiotepa (substance) [SNOMED CT concept]
- thiotepa [ATC Code]
- thiotepa [Substance BNPC]
- thiotepa [SNOMED Notion]
Validated automatic mappings to BTNT
- thiotepa [ATC Code]

Keyword's position in hierarchy(ies) :

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