Preferred Label : Thiotepa;
NCIt synonyms : triethylenethiophosphoramide; Triethylene Thiophosphoramide; 1,1',1''-Phosphinothioyldynetrisaziridine; N,N',N''-triethylenethiophosphoramide; 1,1',1-phosphinothioylidynetrisaziridine; TSPA; Thiophosphoramide; Thiophosphamide; Thiofosfamide; Thioplex; Thiophosphoamide;
NCIt related terms : Thio-Tepa; TIO TEF; Tifosyl; STEPA; Tespamine; Tio-tef; N,N', N''-Triethylenethiophosphoramide; TESPA; Oncotiotepa; Tris(1-aziridinyl)phosphine sulfide; 1,1',1''-Phosphinothioylidynetrisaziridine; Thiotef; Thiofozil; Girostan; Tespamin;
NCIt definition : A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide
(TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into
highly reactive ethylenimine groups, which covalently bind to nucleophilic groups
in DNA and demonstrate a preference for the N7 position of guanine bases. This induces
crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both
DNA replication and cell division, and results in both the induction of apoptosis
and the inhibition of cell growth.;
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called alkylating
agents.;
UNII : 905Z5W3GKH;
InChIKey : FOCVUCIESVLUNU-UHFFFAOYSA-N;
CAS number : 52-24-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 52-24-4
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G-SRS /a ;
Drug name : Tepadina;
Molecule name : WR 45312;
Chemical formula : C6H12N3PS;
NSC code : 6396;
Codes from synonyms : NSC0006396; 00340; CDR0000045603; 490;
Origin ID : C875;
UMLS CUI : C0039871;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
