5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Preferred Label : 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase;

MeSH definition : An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.;

MeSH synonym : methionine synthetase; methionine synthase; synthetase, methionine; s-methyltransferase, 5-methyltetrahydrofolate-homocysteine; methyltetrahydrofolate homocysteine methyltransferase; homocysteine methyltransferase, methyltetrahydrofolate; methyltransferase, methyltetrahydrofolate homocysteine; synthase, methionine; tetrahydropteroylglutamate methyltransferase; methyltransferase, tetrahydropteroylglutamate;

MeSH hyponym : vitamin B12-Dependent methionine synthase; vitamin B12-Independent methionine synthase;

MeSH CAS label : 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase;

MeSH Related Number : 9033-23-2 (CAS RN);

Registry Number MeSH : EC 2.1.1.13;

MeSH annotation : /defic: consider also HOMOCYSTINURIA; DF: note short X ref; /defic: consider also HOMOCYSTINURIA;

Wikipedia link : https://en.wikipedia.org/wiki/Methionine synthase;

Is substance : O;

UNII : EC 2.1.1.13;

Details

Origin ID

D013766;

UMLS CUI

C0039676;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 5-Methyltetrahydrofolate homocysteine methyltransferase [LOINC component]
- 5-methyltetrahydrofolate-homocysteine methyltransferase [ORDO Gene]
- 5-methyltetrahydrofolate-homocysteine methyltransferase [SNOMED Notion]
- 5-methyltetrahydrofolate-homocysteine methyltransferase [HGNC gene]
- 5-methyltetrahydrofolate-homocysteine methyltransferase (substance) [SNOMED CT concept]
- 5-methyltetrahydrofolate-homocysteine s-methyltransferase [OMIM gene]
- Homocystinuria without methylmalonic aciduria [ORDO Disease]
- Methionine Synthase [NCIt concept]
Indexing information
- N-(4-((2-(2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl)methyl)amino)-3-bromobenzoyl)glutamic acid [MeSH Supplementary Concept]
- diethyl N-(4-((2-(2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl)methyl)amino)-3-bromobenzoyl)glutamate [MeSH Supplementary Concept]
Manual NTBT mappings (CISMeF)
- Disorder of methionine cycle and sulfur amino acid metabolism [ORDO Disease]
Record concept(s)
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase [MeSH concept]
- vitamin B12-Dependent methionine synthase [MeSH concept]
- vitamin B12-Independent methionine synthase [MeSH concept]
Related MeSH Supplementary Concept(s)
- MTR protein, human [MeSH Supplementary Concept]
- arakawa syndrome 2 [MeSH Supplementary Concept]
See also
- homocystinuria [MeSH Descriptor]
See also inter- (CISMeF)
- Homocystinuria without methylmalonic aciduria [ICD-11 More detail]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 5-Methyltetrahydrofolate homocysteine methyltransferase [LOINC component]
- 5-methyltetrahydrofolate-homocysteine methyltransferase [SNOMED Notion]
- 5-methyltetrahydrofolate-homocysteine methyltransferase (substance) [SNOMED CT concept]

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