farnesyl-diphosphate farnesyltransferase

Preferred Label : farnesyl-diphosphate farnesyltransferase;

MeSH definition : The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.;

MeSH synonym : fpp-fpp farnesyl transferase; farnesyl transferase, fpp-fpp; transferase, fpp-fpp farnesyl; synthase, squalene; synthetase, squalene; farnesyldiphosphate-farnesyldiphosphate farnesyltransferase; presqualene-diphosphate synthase; presqualene diphosphate synthase; farnesyldiphosphate farnesyldiphosphate farnesyltransferase; farnesyltransferase, farnesyl-diphosphate; farnesyltransferase, farnesyldiphosphate-farnesyldiphosphate; fpp fpp farnesyl transferase; squalene synthase; squalene synthetase; synthase, presqualene-diphosphate; farnesyl diphosphate farnesyltransferase;

Registry Number MeSH : EC 2.5.1.21;

Wikipedia link : https://en.wikipedia.org/wiki/Farnesyl-diphosphate farnesyltransferase;

Is substance : O;

UNII : EC 2.5.1.21;

Details

Origin ID

D013186;

UMLS CUI

C0597790;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid [MeSH Supplementary Concept]
- 1-(4-((4-chloro-2-((2-chlorophenyl)(hydroxy)methyl)phenyl)(2,2-dimethylpropyl)amino)-4-oxobutanoyl)piperidine-3-carboxylic acid [MeSH Supplementary Concept]
- 3-((2-benzyl-6-(3-hydroxy-4-methoxypyrrolidin-1-yl)pyridin-3-yl)ethynyl)quinuclidin-3-ol [MeSH Supplementary Concept]
- 3-((2-benzyl-6-(3-methoxypropyloxy)pyridin-3-yl)ethynyl)quinuclidin-3-ol [MeSH Supplementary Concept]
- 3-(4-(pyrid-4-yl)phenyl)-3-hydroxyquinuclidine [MeSH Supplementary Concept]
- 3-(biphenyl-4-yl)-3-hydroxyquinuclidine [MeSH Supplementary Concept]
- 3-(biphenyl-4-yl)quinuclidine [MeSH Supplementary Concept]
- A 87049 [MeSH Supplementary Concept]
- BMS 187745 [MeSH Supplementary Concept]
- BMS 188494-04 [MeSH Supplementary Concept]
- CP 225917 [MeSH Supplementary Concept]
- ER 27856 [MeSH Supplementary Concept]
- ER 28448 [MeSH Supplementary Concept]
- F 10863B [MeSH Supplementary Concept]
- N-homogeranyl-N-methyl-N'-farnesylformamidine [MeSH Supplementary Concept]
- TAN 1607A [MeSH Supplementary Concept]
- YM 53601 [MeSH Supplementary Concept]
- bisabosqual A [MeSH Supplementary Concept]
- phomoidride C [MeSH Supplementary Concept]
- phomoidride D [MeSH Supplementary Concept]
- schizostatin [MeSH Supplementary Concept]
- squalestatin 1 [MeSH Supplementary Concept]
- squalestatin 2 [MeSH Supplementary Concept]
- squalestatin 3 [MeSH Supplementary Concept]
- viridiofungin A [MeSH Supplementary Concept]
- viridiofungin B [MeSH Supplementary Concept]
- viridiofungin C [MeSH Supplementary Concept]
- zaragozic acid B [MeSH Supplementary Concept]
- zaragozic acid C [MeSH Supplementary Concept]
- zaragozic acid D [MeSH Supplementary Concept]
- zaragozic acid D(2) [MeSH Supplementary Concept]
- zaragozic acid D3 [MeSH Supplementary Concept]
Record concept(s)
- Farnesyl-Diphosphate farnesyltransferase [MeSH concept]
Related MeSH Supplementary Concept(s)
- CrtM protein, staphylococcus aureus [MeSH Supplementary Concept]
- ERG9 protein, S cerevisiae [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Farnesyl-diphosphate farnesyltransferase (substance) [SNOMED CT concept]
- farnesyl-diphosphate farnesyltransferase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients