podophyllotoxin

Preferred Label : podophyllotoxin;

MeSH definition : A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.;

MeSH synonym : podofilox;

CISMeF synonym : ardern brand of podophyllotoxin; canderm brand of podophyllotoxin; fides ecopharma brand of podophyllotoxin; hamilton brand of podophyllotoxin; newport brand of podophyllotoxin; oclassen brand of podophyllotoxin; paddock brand of podophyllotoxin; paladin brand of podophyllotoxin; stiefel brand of podophyllotoxin; wolff brand of podophyllotoxin; yamanouchi brand of podophyllotoxin;

MeSH hyponym : podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer; podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer; condyline; wartec; podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer; podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer; Podocon-25; condylox; Warticon; Podofilm;

Related MeSH term : CPH86; epipodophyllotoxin;

MeSH CAS label : Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-;

MeSH Related Number : podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer; podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer; podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer; podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer; 4375-06-8 ((5R-(5 alpha,5a alpha,8a alpha,9 beta))-isomer); 4375-07-9 ((5R-(5 alpha,5a beta,8a alpha,9 beta))-isomer); 477-47-4 ((5R-(5 alpha,5a alpha,8a alpha,9 alpha))-isomer); 518-28-5 (Podophyllotoxin); 55568-79-1 ((5R-(5 alpha,5a alpha,8a beta,9 alpha))-isomer);

Registry Number MeSH : 518-28-5;

Related CAS MeSH : 4375-06-8 (Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer); 55568-79-1 (Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer); 4375-07-9 (Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer); 477-47-4 (Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer);

MeSH annotation : /biosyn permitted if by plant;

Wikipedia link : https://en.wikipedia.org/wiki/Podophyllotoxin;

Is substance : O;

UNII : L36H50F353;

InChIKey : YJGVMLPVUAXIQN-XVVDYKMHSA-N;

Details

Origin ID

D011034;

UMLS CUI

C0032334;

ATC code(s)
- podophyllotoxin [ATC Code]
ATC code(s)
- podophyllotoxin [ATC Code]
- podophyllotoxin derivatives [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Epipodophyllotoxin Compound [NCIt concept]
CISMeF manual mappings
- podophyllotoxin [Substance BNPC]
Currated CISMeF NLP mapping
- Podofilox [NCIt concept]
- Podophyllotoxin [ICD-11 Extension code]
- Podophyllotoxin [ICHI extension code]
- Podophyllotoxin (substance) [SNOMED CT concept]
- podophyllotoxin [SNOMED Notion]
False automatic mappings
- Podophyllin [Bloc CIM-11]
- Podophyllum resin (substance) [SNOMED CT concept]
- podophyllum (resin) [Substance BNPC]
- podophyllum resin [SNOMED Notion]
Pharmacological action(s)
- antineoplastic agents, phytogenic [MeSH Descriptor]
- keratolytic agents [MeSH Descriptor]
- tubulin modulators [MeSH Descriptor]
Record concept(s)
- CPH86 [MeSH concept]
- Podocon-25 [MeSH concept]
- condyline [MeSH concept]
- condylox [MeSH concept]
- epipodophyllotoxin [MeSH concept]
- podophyllotoxin [MeSH concept]
- podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer [MeSH concept]
- podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer [MeSH concept]
- podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer [MeSH concept]
- podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer [MeSH concept]
- wartec [MeSH concept]
Related MeSH Supplementary Concept(s)
- 11-oxo-13-deoxo-4'-demethylepipodophyllotoxin 4-(N-(2-(N',N'-dimethylaminoethyl)))carbamate [MeSH Supplementary Concept]
- 2-azapodophyllotoxin [MeSH Supplementary Concept]
- 2-fluoropodophyllotoxin [MeSH Supplementary Concept]
- 2-hydroxy-4'-demethyldesoxypodophyllotoxin [MeSH Supplementary Concept]
- 4'-O-demethyl-4-((4-hydroxymethyl)-1,2,3-triazol-1-yl)-4-deoxypodophyllotoxin cyclopentyl carbamate [MeSH Supplementary Concept]
- 4'-O-demethyl-4-deoxypodophyllotoxin-4'-yl 4-((6-(2-(5-fluorouracil-yl)acetamido)hexyl)amino)-4-oxobutanoate [MeSH Supplementary Concept]
- 4'-demethyldeoxypodophyllotoxin-4-O-glucopyranoside [MeSH Supplementary Concept]
- 4'-demethyldesoxypodophyllotoxin [MeSH Supplementary Concept]
- 4'-demethylepipodophyllic acid [MeSH Supplementary Concept]
- 4'-demethylepipodophyllotoxin [MeSH Supplementary Concept]
- 4'-demethylepipodophyllotoxin 4-(N-(2-(N',N'-dimethylaminoethyl)))carbamate [MeSH Supplementary Concept]
- 4'-demethylepipodophyllotoxin-9 beta-glucopyranoside [MeSH Supplementary Concept]
- 4-((4'-benzylpiperdin-4-yl)amino)-4'-O-demethylepipodophyllotoxin [MeSH Supplementary Concept]
- 4-((4-(pyrrolidin-1-ylmethyl)phenyl)amino)-4'-O-demethyl-4-epipodophyllotoxin [MeSH Supplementary Concept]
- 4-(4-methylpiperazinyl)sulfonamido-4'-O-demethyl-4-desoxypodophyllotoxin [MeSH Supplementary Concept]
- 4-(O-methyl(orthocyanophenyl-1,2,3-triazol-4yl))podophyllotoxin [MeSH Supplementary Concept]
- 4-(benzoylthioureido)-4'-demethyl-4-desoxypodophyllotoxin [MeSH Supplementary Concept]
- 4-N-(4-nitrophenylpiperazinyl)-4'-O-demethyl-4-deoxypodophyllotoxin [MeSH Supplementary Concept]
- 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin [MeSH Supplementary Concept]
- 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether [MeSH Supplementary Concept]
- 4-O-butanoyl-4'-demethylpodophyllotoxin [MeSH Supplementary Concept]
- 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate [MeSH Supplementary Concept]
- 4-aza-2,3-didehydropodophyllotoxin [MeSH Supplementary Concept]
- 4-aza-podophyllotoxin [MeSH Supplementary Concept]
- 4-demethyl-picropodophyllotoxin 7'-O-glucopyranoside [MeSH Supplementary Concept]
- 4-morpholinosulfonamido-4'-O-demethyl-4-desoxypodophyllotoxin [MeSH Supplementary Concept]
- 4beta-(1,3,4-oxadiazole-2-amino)-podophyllotoxin [MeSH Supplementary Concept]
- 5'-desmethyldeoxypodophyllotoxin [MeSH Supplementary Concept]
- 5-methoxydehydropodophyllotoxin [MeSH Supplementary Concept]
- 5-methoxypodophyllotoxin [MeSH Supplementary Concept]
- 6-methoxypodophyllotoxin [MeSH Supplementary Concept]
- 6-methoxypodophyllotoxin 7-O-n-hexanoate [MeSH Supplementary Concept]
- Adva-27a podophyllotoxin [MeSH Supplementary Concept]
- BEAM protocol [MeSH Supplementary Concept]
- CECA protocol [MeSH Supplementary Concept]
- CIP-36 [MeSH Supplementary Concept]
- DeNK 611 [MeSH Supplementary Concept]
- EVAC protocol [MeSH Supplementary Concept]
- F14512 [MeSH Supplementary Concept]
- GP 11 [MeSH Supplementary Concept]
- GP 7 [MeSH Supplementary Concept]
- L1EPO agent [MeSH Supplementary Concept]
- LJ12 compound [MeSH Supplementary Concept]
- N-(aminosulfonyl)-4-podophyllotoxin [MeSH Supplementary Concept]
- N-podophyllic acid-N''-(4-(2,2,6,6-tetramethyl-1-piperidinyloxy))thiosemicarbazide [MeSH Supplementary Concept]
- NK 611 [MeSH Supplementary Concept]
- OAMDP compound [MeSH Supplementary Concept]
- P-3F compound [MeSH Supplementary Concept]
- RATE protocol [MeSH Supplementary Concept]
- VIP protocol 2 [MeSH Supplementary Concept]
- VPA protocol [MeSH Supplementary Concept]
- VPIV protocol [MeSH Supplementary Concept]
- ZM-66 compound [MeSH Supplementary Concept]
- alpha-peltatin [MeSH Supplementary Concept]
- beta-peltatin A methyl ether [MeSH Supplementary Concept]
- beta-peltatin A-alpha-L-arabinofuranoside [MeSH Supplementary Concept]
- compound 27-487 [MeSH Supplementary Concept]
- deoxypodophyllotoxin [MeSH Supplementary Concept]
- etoplatin-N2beta [MeSH Supplementary Concept]
- mitopodozide [MeSH Supplementary Concept]
- picropodophyllin [MeSH Supplementary Concept]
- picropodophyllin-1-ethyl ether [MeSH Supplementary Concept]
- picropolygamain [MeSH Supplementary Concept]
- podophyllic acid [MeSH Supplementary Concept]
- podophyllic acid piperidyl hydrazone nitroxide radical [MeSH Supplementary Concept]
- podophyllotoxin 4-O-glucopyranoside [MeSH Supplementary Concept]
- podophyllotoxin acetate [MeSH Supplementary Concept]
- quinazolino-4-amidopodophyllotoxin [MeSH Supplementary Concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Podofilox [NCIt concept]
- Podophyllotoxin [ICD-11 Extension code]
- Podophyllotoxin (substance) [SNOMED CT concept]
- Product containing podophyllotoxin (medicinal product) [SNOMED CT concept]
- podophyllotoxin [ATC Code]
- podophyllotoxin [Substance BNPC]
- podophyllotoxin [SNOMED Notion]
Validated automatic mappings to BTNT
- podophyllotoxin [ATC Code]

Keyword's position in hierarchy(ies) :

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