Epipodophyllotoxin Compound

Preferred Label : Epipodophyllotoxin Compound;

NCIt related terms : epipodophyllotoxin;

NCIt definition : An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor.;

Codes from synonyms : CDR0000044822;

Details

Origin ID

C1331;

UMLS CUI

C0086243;

Automatic exact mappings (from CISMeF team)
- podophyllotoxin [MeSH Descriptor]
Currated CISMeF NLP mapping
- epipodophyllotoxin [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- epipodophyllotoxin [MeSH concept]

Keyword's position in hierarchy(ies) :

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