NCIt definition : An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind
to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules,
resulting in the accumulation of single- or double-strand DNA breaks, the inhibition
of DNA replication and transcription, and apoptotic cell death.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin
is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase
inhibitor.;