Preferred Label : neoplasm proteins;
MeSH definition : Proteins whose abnormal expression (gain or loss) are associated with the development,
growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS,
NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins
have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they
are detectable in cells and body fluids as monitors for the presence or growth of
tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation,
whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss
of growth control and progression of the neoplasm.;
MeSH synonym : proteins, neoplasm;
MeSH annotation : IM & coord with specific protein (IM) specific histol type (IM) specific organ/neoplasms
term (IM); Manual 24.4.4.4;
Is substance : O;
Origin ID : D009363;
UMLS CUI : C0027642;
Allowable qualifiers
- Indexing information
- necdin [MeSH Supplementary Concept]
- neugrin [MeSH Supplementary Concept]
- nidogen [MeSH Supplementary Concept]
- Metaterm(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- ABP 38 [MeSH Supplementary Concept]
- See also
- Semantic type(s)
Proteins whose abnormal expression (gain or loss) are associated with the development,
growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS,
NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins
have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they
are detectable in cells and body fluids as monitors for the presence or growth of
tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation,
whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss
of growth control and progression of the neoplasm.
