Preferred Label : isocitrate dehydrogenase;
MeSH definition : An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate
and NAD to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria.
The enzyme requires Mg2 , Mn2 ; it is activated by ADP, citrate, and Ca2 , and inhibited
by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric
acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP enzyme is EC 1.1.1.42.)
EC 1.1.1.41.;
MeSH synonym : dehydrogenase, isocitrate; dehydrogenase, nad isocitrate; isocitrate dehydrogenase (nad ); nad isocitrate dehydrogenase; isocitrate dehydrogenase, nad;
MeSH hyponym : isocitrate Dehydrogenase-I; Isocitrate Dehydrogenase I;
MeSH CAS label : Isocitrate:NAD oxidoreductase (decarboxylating);
Registry Number MeSH : EC 1.1.1.41;
Wikipedia link : https://en.wikipedia.org/wiki/Isocitrate dehydrogenase;
Is substance : O;
UNII : EC 1.1.1.41;
Origin ID : D007521;
UMLS CUI : C0022157;
ATC code(s)
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- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
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An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate
and NAD to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria.
The enzyme requires Mg2 , Mn2 ; it is activated by ADP, citrate, and Ca2 , and inhibited
by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric
acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP enzyme is EC 1.1.1.42.)
EC 1.1.1.41.
