hirudins - CISMeF

Preferred Label : hirudins;

MeSH definition : Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.;

MeSH hyponym : hirudin;

MeSH Related Number : hirudin; 8001-27-2;

Related CAS MeSH : 8001-27-2 (Hirudin);

Wikipedia link : https://en.wikipedia.org/wiki/Hirudin;

Is substance : O;

Details

Origin ID

D006629;

UMLS CUI

C1451270;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Hirudin and derivatives (substance) [Inactive SNOMED CT concept]
Pharmacological action(s)
- antithrombins [MeSH Descriptor]
- fibrinolytic agents [MeSH Descriptor]
Record concept(s)
- hirudin [MeSH concept]
- hirudins [MeSH concept]
Related MeSH Supplementary Concept(s)
- 5rolGLP-HV fusion peptide [MeSH Supplementary Concept]
- CX 397 [MeSH Supplementary Concept]
- LU 52369 [MeSH Supplementary Concept]
- LU 58463 [MeSH Supplementary Concept]
- M23 urokinase [MeSH Supplementary Concept]
- N(alpha)-acetylhirudin(45-65) [MeSH Supplementary Concept]
- RGD-hirudin [MeSH Supplementary Concept]
- SAK-RGD-K2-Hir [MeSH Supplementary Concept]
- SAK-RGD-K2-Hirul [MeSH Supplementary Concept]
- beta-naphthylsulfonyl-(d-Pip)-Ada-Abu-DFEEIPEEYLQ-OH-AcOH [MeSH Supplementary Concept]
- beta-naphthylsulfonyl-R-(d-Pip)-Ada-Abu-DYEPIPEEA-(Cha)-(d-Glu)-OH-AcOH [MeSH Supplementary Concept]
- bivalirudin [MeSH Supplementary Concept]
- desirudin [MeSH Supplementary Concept]
- hirudin (1-47) [MeSH Supplementary Concept]
- hirudin (1-49), leech [MeSH Supplementary Concept]
- hirudin (1-51) [MeSH Supplementary Concept]
- hirudin (42-63) [MeSH Supplementary Concept]
- hirudin (45-64) [MeSH Supplementary Concept]
- hirudin (53-64) [MeSH Supplementary Concept]
- hirudin (53-64), RGD- [MeSH Supplementary Concept]
- hirudin (54-64), N(alpha)-dinitrofluorobenzyl- [MeSH Supplementary Concept]
- hirudin (54-65) [MeSH Supplementary Concept]
- hirudin -like fusion protein 8067, human [MeSH Supplementary Concept]
- hirudin HV1 [MeSH Supplementary Concept]
- hirudin HV2 [MeSH Supplementary Concept]
- hirudin HV3 [MeSH Supplementary Concept]
- hirudin PA [MeSH Supplementary Concept]
- hirudin, Lys(47)- [MeSH Supplementary Concept]
- hirudisin [MeSH Supplementary Concept]
- hirugen [MeSH Supplementary Concept]
- hirulog 3-thrombin complex [MeSH Supplementary Concept]
- hirulog-B2 [MeSH Supplementary Concept]
- hirulog-like peptide [MeSH Supplementary Concept]
- hirutonin-2 [MeSH Supplementary Concept]
- hirutonin-6 [MeSH Supplementary Concept]
- lepidurin [MeSH Supplementary Concept]
- lepirudin [MeSH Supplementary Concept]
- polyethyleneglycol-hirudin [MeSH Supplementary Concept]
- pseudohirudin [MeSH Supplementary Concept]
- recombinant hirudin, Ile(1)-Thr(2)-63-desulfato- [MeSH Supplementary Concept]
Related MeSH term(s)
- hirudin therapy [MeSH Descriptor]
See also
- hirudin therapy [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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