Preferred Label : chenodeoxycholic acid;
MeSH definition : A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent
to solubilize fats for intestinal absorption and is reabsorbed by the small intestine.
It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.;
MeSH synonym : acid, chenic; acid, gallodesoxycholic; henohol; gallodesoxycholic acid; acid, chenique; acid, chenodeoxycholic; chenodiol; chenic acid; chenique acid;
CISMeF synonym : solvay brand of chenodeoxycholic acid; estedi brand of chenodeoxycholic acid; zambon brand of chenodeoxycholic acid; tramedico brand of chenodeoxycholic acid; falk brand of chenodeoxycholic acid; antigen brand of chenodeoxycholic acid;
MeSH hyponym : sodium chenodeoxycholate; chenodeoxycholate; quenocol; quenobilan; chenofalk; chenix; Chenophalk; Chenodeoxycholate, Sodium;
MeSH CAS label : Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)-;
MeSH Related Number : 474-25-9 (Chenodeoxycholic acid);
Registry Number MeSH : 474-25-9;
MeSH annotation : a bile acid; /biosyn /physiol permitted;
Wikipedia link : https://en.wikipedia.org/wiki/Chenodeoxycholic acid;
Codes EINECS : 207-481-8;
Is substance : O;
UNII : 0GEI24LG0J;
InChIKey : RUDATBOHQWOJDD-BSWAIDMHSA-N;
Origin ID : D002635;
UMLS CUI : C0008024;
ATC code(s)
ATC code(s)
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
- bile acid [Artificial nutrition thesaurus concept]
CISMeF manual mappings
Pharmacological action(s)
Record concept(s)
Related MeSH Supplementary Concept(s)
- HS 1200 [MeSH Supplementary Concept]
- HS-1199 [MeSH Supplementary Concept]
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent
to solubilize fats for intestinal absorption and is reabsorbed by the small intestine.
It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
https://www.has-sante.fr/jcms/p_3186712/fr/ocaliva
2020
false
false
false
France
obeticholic acid
adult
insurance, health, reimbursement
treatment outcome
drug therapy, combination
ursodeoxycholic acid
Primary biliary cholangitis
Primary Biliary Cholangitis
administration, oral
evaluation of the transparency committee
obeticholic acid
chenodeoxycholic acid
liver cirrhosis, biliary
chenodeoxycholic acid
chenodeoxycholic acid
---
https://ansm.sante.fr/informations-de-securite/ocaliva-r-v-acide-obeticholique-renforcement-de-ladaptation-posologique-chez-les-patients-atteints-de-cholangite-biliaire-primitive-cbp-avec-insuffisance-hepatique-moderee-a-severe
2018
false
false
false
France
French
guidelines for drug use
pharmacovigilance note
administration, oral
obeticholic acid
cholangitis
Primary cholangitis (disorder)
hepatic insufficiency
continuity of patient care
liver function tests
Hepatic decompensation
disease progression
Child-Pugh score class A (finding)
Child-Pugh score class B (finding)
Child-Pugh score class C (finding)
obeticholic acid
drug monitoring
obeticholic acid
chenodeoxycholic acid
chenodeoxycholic acid
chenodeoxycholic acid
---
https://www.has-sante.fr/portail/jcms/c_2865403/fr/chenodeoxycholic-acid-leadiant
2018
false
false
false
France
French
chenodeoxycholic acid
chenodeoxycholic acid
adult
child
infant
orphan drug production
xanthomatosis, cerebrotendinous
administration, oral
adolescent
treatment outcome
evaluation of the transparency committee
Disorder of bile acid synthesis
cholestanetriol 26-Monooxygenase
---
https://www.ema.europa.eu/medicines/human/EPAR/chenodeoxycholic-acid-leadiant-previously-known-chenodeoxycholic-acid-sigma-tau
2017
false
false
false
United Kingdom
French
English
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
chenodeoxycholic acid
chenodeoxycholic acid
chenodeoxycholic acid
adult
child
infant
orphan drug production
xanthomatosis, cerebrotendinous
Product containing chenodeoxycholic acid (medicinal product)
administration, oral
product surveillance, postmarketing
adolescent
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
---
https://www.has-sante.fr/portail/jcms/c_2773278/fr/ocaliva
https://www.has-sante.fr/portail/jcms/c_2773278/fr/ocaliva-acide-obeticholique-acide-biliaire
2017
false
false
false
France
French
treatment outcome
orphan drug production
cholangitis
Primary cholangitis (disorder)
obeticholic acid
obeticholic acid
adult
drug therapy, combination
ursodeoxycholic acid
administration, oral
evaluation of the transparency committee
guidelines for drug use
chenodeoxycholic acid
chenodeoxycholic acid
---
obeticholic acid
https://www.ema.europa.eu/medicines/human/EPAR/Ocaliva
2016
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
orphan drug production
drug approval
europe
cholangitis
Primary cholangitis (disorder)
obeticholic acid
obeticholic acid
obeticholic acid
adult
drug therapy, combination
ursodeoxycholic acid
administration, oral
risk assessment
pregnancy
breast feeding
drug interactions
product surveillance, postmarketing
drug evaluation, preclinical
chenodeoxycholic acid
chenodeoxycholic acid
chenodeoxycholic acid
---