MeSH definition : Agents that increase calcium influx into calcium channels of excitable tissues. This
causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well
as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective
calcium agonists have the potential to combat cardiac failure and endocrinological
disorders. They have been used primarily in experimental studies in cell and tissue
culture.;
Agents that increase calcium influx into calcium channels of excitable tissues. This
causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well
as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective
calcium agonists have the potential to combat cardiac failure and endocrinological
disorders. They have been used primarily in experimental studies in cell and tissue
culture.