botulinum toxins

Preferred Label : botulinum toxins;

MeSH definition : Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.;

MeSH synonym : botulinum toxin; clostridium botulinum toxins; toxins, clostridium botulinum; toxins, botulinum; toxin, botulinum; botulin; Botulinum Neurotoxins; Neurotoxins, Botulinum; Botulinum Neurotoxin; Neurotoxin, Botulinum;

CISMeF synonym : botulinum toxins, clostridium;

Registry Number MeSH : EC 3.4.24.69;

MeSH annotation : /antag permitted but consider also BOTULINUM ANTITOXIN;

Wikipedia link : https://en.wikipedia.org/wiki/Botulinum toxin;

Is substance : O;

UNII : EC 3.4.24.69;

Details

Origin ID

D001905;

UMLS CUI

C0006055;

ATC code(s)
- botulinum toxin [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- Clostridium botulinum toxoid [MeSH Supplementary Concept]
MedlinePlus topic(s)
- botox [MedlinePlus Topic]
- botulism [MedlinePlus Topic]
Pharmacological action(s)
- Acetylcholine Release Inhibitors [MeSH Descriptor]
- anti-dyskinesia agents [MeSH Descriptor]
- neurotoxins [MeSH Descriptor]
- poisons [MeSH Descriptor]
Record concept(s)
- botulinum toxins [MeSH concept]
Related MeSH Supplementary Concept(s)
- CNBTX-A [MeSH Supplementary Concept]
- NTNH protein, clostridium botulinum [MeSH Supplementary Concept]
- SXN101959 [MeSH Supplementary Concept]
- botulinum toxin type C [MeSH Supplementary Concept]
- botulinum toxin type D [MeSH Supplementary Concept]
- botulinum toxin type E [MeSH Supplementary Concept]
- botulinum toxin type F [MeSH Supplementary Concept]
- botulinum toxin type G [MeSH Supplementary Concept]
- clostridium botulinum L toxin [MeSH Supplementary Concept]
- clostridium botulinum LL toxin [MeSH Supplementary Concept]
- clostridium botulinum M toxin [MeSH Supplementary Concept]
- exoenzyme C3, clostridium botulinum [MeSH Supplementary Concept]
- hemagglutinin 33 protein, clostridium botulinum [MeSH Supplementary Concept]
- rimabotulinumtoxinB [MeSH Supplementary Concept]
See also
- botulism [MeSH Descriptor]
- cholinergic agents [MeSH Descriptor]
- clostridium botulinum [MeSH Descriptor]
See also (suggested by CISMeF)
- botulinum antitoxin [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Botulinum Toxin [NCIt concept]
- Clostridium botulinum toxin [LOINC component]
- Clostridium botulinum toxin (substance) [SNOMED CT concept]
- Clostridium botulinum toxin agent (substance) [Inactive SNOMED CT concept]
- Product containing Clostridium botulinum toxin (medicinal product) [SNOMED CT concept]
- botulinum toxin [ATC Code]
- clostridium botulinum toxin [SNOMED Notion]
Validated automatic mappings to BTNT
- Botulinum Toxin Type A [NCIt concept]
- Botulinum toxin type A [SMS substance]
- Botulinum toxin type A (substance) [SNOMED CT concept]
- CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE A (150KD), FREE OF COMPLEXING PROTEINS [SMS substance]
- botulinum toxin [ATC Code]

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