immunotoxins - CISMeF

Preferred Label : immunotoxins;

MeSH definition : Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.;

MeSH synonym : cytotoxin-antibody conjugates; toxin antibody hybrids; hybrids, toxin-antibody; antibody-toxin conjugates; immunotoxin; monoclonal antibody-toxin conjugates; hybrids, antibody-toxin; antibody toxin hybrids; cytotoxin antibody conjugates; affinotoxins; toxin antibody conjugates; toxin-antibody hybrids; monoclonal antibody toxin conjugates; antibody toxin conjugates; antibody-toxin conjugates, monoclonal; antibody-toxin hybrids; conjugates, monoclonal antibody-toxin; conjugates, cytotoxin-antibody; toxin-antibody conjugates; conjugates, antibody-toxin; conjugates, toxin-antibody; Antibody-Toxin Conjugate; Antibody Toxin Conjugate; Conjugate, Antibody-Toxin; Antibody-Toxin Hybrid; Antibody Toxin Hybrid; Hybrid, Antibody-Toxin; Cytotoxin-Antibody Conjugate; Conjugate, Cytotoxin-Antibody; Cytotoxin Antibody Conjugate; Monoclonal Antibody-Toxin Conjugate; Antibody-Toxin Conjugate, Monoclonal; Conjugate, Monoclonal Antibody-Toxin; Monoclonal Antibody Toxin Conjugate; Toxin-Antibody Hybrid; Hybrid, Toxin-Antibody; Toxin Antibody Hybrid; Toxin-Antibody Conjugate; Conjugate, Toxin-Antibody; Toxin Antibody Conjugate; Affinotoxin;

MeSH Hyperonym : toxins, chimeric; targeted toxins; Toxins, Targeted; Chimeric Toxins; Toxin Conjugates; Conjugates, Toxin; Toxin Carriers; Carriers, Toxin; Toxin Conjugate; Conjugate, Toxin; Chimeric Toxin; Toxin, Chimeric; Toxin Carrier; Carrier, Toxin; Targeted Toxin; Toxin, Targeted;

MeSH annotation : coordinate IM with specific toxin (IM) specific immune substance (NIM);

Wikipedia link : https://en.wikipedia.org/wiki/Immunotoxins;

Is substance : O;

action pharmacologique : O;

Details

Origin ID

D000922;

UMLS CUI

C0021084;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Antitoxin [ICD-11 Extension code]
- Antitoxin [ICHI extension code]
- Antitoxin (substance) [SNOMED CT concept]
- antitoxin [SNOMED Notion]
Currated CISMeF NLP mapping
- Immunotoxin [NCIt concept]
Indexing information
- 4-desacetylvinblastine 3-carboxyhydrazide monoclonal antibody conjugates [MeSH Supplementary Concept]
- 4-desacetylvinblastine hydrazide-monoclonal antibody KS1-4 conjugate [MeSH Supplementary Concept]
- 924-RAC [MeSH Supplementary Concept]
- B3(Fv)-PE38KDEL recombinant immunotoxin [MeSH Supplementary Concept]
- BAY 79-4620 [MeSH Supplementary Concept]
- BMS-191352 protein, recombinant [MeSH Supplementary Concept]
- BR96 sFv-PE40 [MeSH Supplementary Concept]
- BR96-doxorubicin immunoconjugate [MeSH Supplementary Concept]
- CD4-Pseudomonas toxin [MeSH Supplementary Concept]
- DA7 immunotoxin [MeSH Supplementary Concept]
- DAB(389) interleukin-7 [MeSH Supplementary Concept]
- DAB(389)-interleukin 4 [MeSH Supplementary Concept]
- DAB(486)-interleukin 2 [MeSH Supplementary Concept]
- DAB389CD4 [MeSH Supplementary Concept]
- DT 2219 immunotoxin [MeSH Supplementary Concept]
- DT390-anti-CD3sFv [MeSH Supplementary Concept]
- EDNsFv anti-transferrin receptor [MeSH Supplementary Concept]
- FN18-CRM9 [MeSH Supplementary Concept]
- G28-5 sFv-PE40 [MeSH Supplementary Concept]
- HAR-TX beta 2 protein, recombinant [MeSH Supplementary Concept]
- HER2 affitoxin [MeSH Supplementary Concept]
- IL-2-PE40 chimeric protein, recombinant [MeSH Supplementary Concept]
- IT-87 immunotoxin [MeSH Supplementary Concept]
- K-18 conjugate [MeSH Supplementary Concept]
- Ki-3(scFv)-ETA' [MeSH Supplementary Concept]
- MBP-PE40 [MeSH Supplementary Concept]
- MBr1-Res immunotoxin, aspergillus [MeSH Supplementary Concept]
- ME20.4 IgG-saporin [MeSH Supplementary Concept]
- MLN8866 [MeSH Supplementary Concept]
- N901 MoAb-blocked ricin conjugate [MeSH Supplementary Concept]
- OLX 209 [MeSH Supplementary Concept]
- PSMA ADC [MeSH Supplementary Concept]
- RFB4(dsFv)-PE38 recombinant immunotoxin [MeSH Supplementary Concept]
- RFT5(scFv)-ETA' [MeSH Supplementary Concept]
- SS(dsFv)PE38 [MeSH Supplementary Concept]
- SS1(dsFv)PE38 [MeSH Supplementary Concept]
- SS1-LR-GGS-8M immunotoxin [MeSH Supplementary Concept]
- T101 FAB fragment-ricin A-chain immunotoxin [MeSH Supplementary Concept]
- XomaZyme [MeSH Supplementary Concept]
- ZENECA ZD0490 [MeSH Supplementary Concept]
- alpha-MSH-melphalan conjugate [MeSH Supplementary Concept]
- anti-VAChT antibody-saporin conjugate immunotoxin [MeSH Supplementary Concept]
- anti-alpha-fetoprotein antibody-daunomycin conjugate [MeSH Supplementary Concept]
- anti-dopamine beta-hydroxylase immunotoxin [MeSH Supplementary Concept]
- anti-tac-SAP [MeSH Supplementary Concept]
- antitac(FV)-PE38 recombinant immunotoxin [MeSH Supplementary Concept]
- coltuximab ravtansine [MeSH Supplementary Concept]
- combotox [MeSH Supplementary Concept]
- doxorubicin-1G3.10-monoclonal antibody conjugate [MeSH Supplementary Concept]
- dt(388) granulocyte-macrophage colony-stimulating factor [MeSH Supplementary Concept]
- fibrinogen-methotrexate conjugate [MeSH Supplementary Concept]
- hypocretin-2-saporin conjugate [MeSH Supplementary Concept]
- immunotoxin LMB-7 [MeSH Supplementary Concept]
- insulin crosslinked to the catalytic fragment A of diphtheria toxin [MeSH Supplementary Concept]
- interleukin 4 (1-129)-PE38KDEL [MeSH Supplementary Concept]
- interleukin 4 (38-37)-PE38KDEL [MeSH Supplementary Concept]
- mitomycin C-anti-alpha-fetoprotein antibody conjugate [MeSH Supplementary Concept]
- mitomycin C-immunoglobulin M antibody conjugate [MeSH Supplementary Concept]
- naratuximab emtansine [MeSH Supplementary Concept]
- oncolysin B [MeSH Supplementary Concept]
- pea seed lectin-methotrexate conjugate [MeSH Supplementary Concept]
- recombinant fusion protein RNase1-IL-2 [MeSH Supplementary Concept]
- retanef [MeSH Supplementary Concept]
- rhodosaminylanthracyclinone antibiotics [MeSH Supplementary Concept]
- urokinase-ATF-SAP-3, recombinant [MeSH Supplementary Concept]
- zolimomab aritox [MeSH Supplementary Concept]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- immunotoxins [MeSH concept]
- targeted toxins [MeSH concept]
- toxins, chimeric [MeSH concept]
See also
- antibodies, bispecific [MeSH Descriptor]
- recombinant fusion proteins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- 192 IgG-saporin [MeSH Supplementary Concept]
- Ado-Trastuzumab Emtansine [MeSH Descriptor]
- BACH 250-rGel [MeSH Supplementary Concept]
- Brentuximab Vedotin [MeSH Descriptor]
- Gemtuzumab [MeSH Descriptor]
- Inotuzumab Ozogamicin [MeSH Descriptor]
- OX7-saporin [MeSH Supplementary Concept]
- SSP-SAP fusion protein, recombinant [MeSH Supplementary Concept]
- anti-VAChT antibody-saporin conjugate immunotoxin [MeSH Supplementary Concept]
- bivatuzumab mertansine [MeSH Supplementary Concept]
- cantuzumab mertansine [MeSH Supplementary Concept]
- deoxypodophyllotoxin [MeSH Supplementary Concept]
- immunotoxin HA22 [MeSH Supplementary Concept]
- lorvotuzumab mertansine [MeSH Supplementary Concept]
UMLS correspondences (same concept)
- Immunotoxin [NCIt concept]

Keyword's position in hierarchy(ies) :

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