Preferred Label : angiotensinogen;
MeSH definition : An alpha-globulin of about 453 amino acids, depending on the species. It is produced
by the liver and secreted into blood circulation. Angiotensinogen is the inactive
precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen
yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.; An alpha-globulin of about 453 amino acids, depending on the species. It is produced
by the liver in response to lowered blood pressure and secreted into blood circulation.
Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body
by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide
ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME)
yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other
enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN
SYSTEM.;
MeSH synonym : hypertensinogen; renin substrate; proangiotensin; renin-substrate; Serpin A8; SERPINA8;
Wikipedia automatic translation : Angiotensin;
MeSH hyponym : renin substrate tetradecapeptide; Tetradecapeptide, Renin Substrate;
MeSH CAS label : angiotensinogen (protein renin substrate);
Registry Number MeSH : 11002-13-4;
Wikipedia link : https://en.wikipedia.org/wiki/Angiotensin;
Is substance : O;
Origin ID : D000808;
UMLS CUI : C0003017;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- H 142 [MeSH Supplementary Concept]
- H 189 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
An alpha-globulin of about 453 amino acids, depending on the species. It is produced
by the liver and secreted into blood circulation. Angiotensinogen is the inactive
precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen
yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.
An alpha-globulin of about 453 amino acids, depending on the species. It is produced
by the liver in response to lowered blood pressure and secreted into blood circulation.
Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body
by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide
ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME)
yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other
enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN
SYSTEM.
