Shelterin Complex

Preferred Label : Shelterin Complex;

MeSH definition : A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).;

MeSH synonym : Complex, Shelterin; Telosome; Telosomes; POT1-TPP1 Shelterin Complex; Complex, POT1-TPP1 Shelterin; POT1 TPP1 Shelterin Complex; Shelterin Complex, POT1-TPP1; Telomere POT1-TPP1 Complex; Complex, Telomere POT1-TPP1; POT1-TPP1 Complex, Telomere; Telomere POT1 TPP1 Complex;

Related MeSH term : Complex, CST; Telomeric Capping Complex; Capping Complex, Telomeric; Complex, Telomeric Capping; Ctc1-Stn1-Ten1 Complex; Complex, Ctc1-Stn1-Ten1; Ctc1 Stn1 Ten1 Complex; Telomeric Stn1 Ten1 Capping Complex;

Details

Origin ID

D000089804;

UMLS CUI

C3889653;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- telomere cap complex [GO term]
Currated CISMeF NLP mapping
- Shelterin [NCIt concept]
- shelterin complex [GO term]
Record concept(s)
- CST Complex [MeSH concept]
- Shelterin Complex [MeSH concept]
- Telomere Cap Complex [MeSH concept]
- Telomeric Stn1-Ten1 Capping Complex [MeSH concept]
Related MeSH Supplementary Concept(s)
- ACD protein, human [MeSH Supplementary Concept]
- POT1 protein, human [MeSH Supplementary Concept]
- POT1 protein, mouse [MeSH Supplementary Concept]
- Pot1 protein, arabidopsis [MeSH Supplementary Concept]
- RAP1 protein, Drosophila [MeSH Supplementary Concept]
- RAP1 protein, S cerevisiae [MeSH Supplementary Concept]
- RAP1 protein, candida albicans [MeSH Supplementary Concept]
- Rap1 protein, S pombe [MeSH Supplementary Concept]
- TERF1 protein, human [MeSH Supplementary Concept]
- TERF2IP protein, human [MeSH Supplementary Concept]
- TERF2IP protein, mouse [MeSH Supplementary Concept]
- TPP1 protein, zebrafish [MeSH Supplementary Concept]
- pot1 protein, S pombe [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Shelterin [NCIt concept]

Keyword's position in hierarchy(ies) :

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