Preferred Label : Tazobactam;
MeSH definition : A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that
enhances the activity of other anti-bacterial agents against beta-lactamase producing
bacteria.;
MeSH hyponym : YTR-830; YTR830;
MeSH CAS label : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-,
4,4-dioxide, (2S,3S,5R)-;
MeSH Related Number : 93528-38-2 (Tazobactam); UXA545ABTT;
UNII : SE10G96M8W;
Origin ID : D000078142;
UMLS CUI : C0075870;
ATC code(s)
Allowable qualifiers
Manual BTNT mappings - CISMeF
MeSH indexing information
Pharmacological action(s)
Record concept(s)
Related MeSH Supplementary Concept(s)
See also inter- (CISMeF)
Semantic type(s)
Validated automatic mappings to BTNT
A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that
enhances the activity of other anti-bacterial agents against beta-lactamase producing
bacteria.
https://www.has-sante.fr/jcms/p_3402033/fr/zerbaxa-ceftolozane/tazobactam-traitement-des-infections-chez-les-enfants-de-la-naissance-a-moins-de-18-ans
2022
false
false
false
France
treatment outcome
insurance, health, reimbursement
drug combinations
Tazobactam
ceftolozane
beta-Lactamase Inhibitors
anti-bacterial agents
ceftolozane and beta-lactamase inhibitor
infant, newborn
infant
adolescent
pseudomonas infections
pseudomonas aeruginosa
Infection caused by Pseudomonas aeruginosa (disorder)
infusions, intravenous
evaluation of the transparency committee
ceftolozane, tazobactam drug combination
child
---
https://ansm.sante.fr/informations-de-securite/Zerbaxa-R-ceftolozane-tazobactam-1-g-0-5-g-poudre-pour-solution-a-diluer-pour-perfusion-RAPPEL-DE-LOT-MONDIAL
2021
false
false
false
France
French
pharmacovigilance note
ceftolozane, tazobactam drug combination
drug contamination
ceftolozane
drug combinations
Safety-Based drug withdrawals
infusions, intravenous
Tazobactam
cephalosporins
penicillanic acid
---
https://ansm.sante.fr/actualites/lantibiotique-zerbaxa-ceftolozane-tazobactam-nest-plus-disponible-en-raison-dun-arret-temporaire-de-la-production
2020
false
false
false
France
French
pharmacovigilance note
drug contamination
anti-bacterial agents
ceftolozane, tazobactam drug combination
ceftolozane sulfate
Tazobactam Sodium
france
ceftolozane and beta-lactamase inhibitor
ceftolozane
Tazobactam
cephalosporins
penicillanic acid
---
https://www.has-sante.fr/jcms/p_3152698/fr/zerbaxa
2020
false
false
false
France
French
treatment outcome
insurance, health, reimbursement
ceftolozane, tazobactam drug combination
drug combinations
ceftolozane
anti-bacterial agents
Tazobactam
ceftolozane and beta-lactamase inhibitor
beta-Lactamase Inhibitors
evaluation of the transparency committee
pseudomonas aeruginosa
pseudomonas infections
Infection Pseudomonas aeruginosa
cephalosporins
penicillanic acid
penicillanic acid
---
http://www.has-sante.fr/portail/jcms/c_2658642/fr/zerbaxa
http://www.has-sante.fr/portail/jcms/c_2658642/fr/zerbaxa-ceftolozane/tazobactam-cephalosporine-et-inhibiteur-de-lactamase
2016
false
false
false
France
French
treatment outcome
ceftolozane, tazobactam drug combination
ceftolozane, tazobactam drug combination
ceftolozane
ceftolozane
anti-bacterial agents
anti-bacterial agents
pyelonephritis
intraabdominal infections
urinary tract infections
complicated intra-abdominal infections
INFECTION AGGRAVATED
infusions, intravenous
beta-Lactamase Inhibitors
beta-Lactamase Inhibitors
aged
drug combinations
ceftolozane and beta-lactamase inhibitor
antibiotic therapy
evaluation of the transparency committee
guidelines for drug use
pseudomonas infections
pseudomonas aeruginosa
Infection caused by extended spectrum beta-lactamase producing bacteria (disorder)
infection due to pseudomonas aeruginosa
cephalosporins
penicillanic acid
penicillanic acid
cephalosporins
penicillanic acid
Tazobactam
Tazobactam
---
https://www.ema.europa.eu/medicines/human/EPAR/Zerbaxa
2015
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
ceftolozane, tazobactam drug combination
ceftolozane, tazobactam drug combination
ceftolozane
ceftolozane
anti-bacterial agents
anti-bacterial agents
pyelonephritis
intraabdominal infections
urinary tract infections
complicated intra-abdominal infections
INFECTION AGGRAVATED
infusions, intravenous
beta-Lactamase Inhibitors
beta-Lactamase Inhibitors
drug monitoring
product surveillance, postmarketing
pregnancy
breast feeding
drug interactions
aged
drug compounding
drug evaluation, preclinical
risk management
drug combinations
ceftolozane and beta-lactamase inhibitor
antibiotic therapy
cephalosporins
penicillanic acid
penicillanic acid
cephalosporins
penicillanic acid
Tazobactam
Tazobactam
---
Summary Basis of Decision (SBD) for Zerbaxa
Zerbaxa 1.5 g /vial, ceftolozane (1 g as ceftolozane sulfate) and tazobactam (0.5
g as tazobactam sodium), powder for solution, intravenous
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailTwo.php?linkID=SBD00247
2015
false
false
false
false
Canada
French
summary of product characteristics
ceftolozane, tazobactam drug combination
ceftolozane, tazobactam drug combination
ceftolozane
ceftolozane
drug combinations
drug approval
canada
ceftolozane sulfate
ceftolozane sulfate
anti-bacterial agents
anti-bacterial agents
beta-Lactamase Inhibitors
beta-Lactamase Inhibitors
intraabdominal infections
complicated intra-abdominal infections
Complicated infection
urinary tract infections
pyelonephritis
infusions, intravenous
treatment outcome
ceftolozane and beta-lactamase inhibitor
antibiotic therapy
cephalosporins
penicillanic acid
penicillanic acid
cephalosporins
penicillanic acid
Tazobactam
Tazobactam
---
http://www.lecrat.eu/?s=Tazocilline
2013
France
French
antibiotic therapy
piperacillin
drug combinations
pregnancy
penicillanic acid
anti-bacterial agents
piperacillin and beta-lactamase inhibitor
drug information
Piperacillin, Tazobactam Drug Combination
Tazobactam
---
http://www.lecrat.eu/?s=Tazobactam
2013
France
French
infant, newborn
beta-Lactamases
pregnancy
enzyme inhibitors
tazobactam
penicillanic acid
drug information
Tazobactam
---
http://www.meddispar.fr/medicaments/3691921
2008
France
French
piperacillin
penicillanic acid
drug combinations
infusions, parenteral
drug prescriptions
legislation, drug
piperacillin and beta-lactamase inhibitor
drug information
Piperacillin, Tazobactam Drug Combination
Tazobactam
---
http://www.meddispar.fr/medicaments/3691944
2008
France
French
penicillanic acid
drug prescriptions
legislation, drug
perfusion
piperacillin
piperacillin and beta-lactamase inhibitor
drug information
Piperacillin, Tazobactam Drug Combination
Tazobactam
---
http://www.has-sante.fr/portail/display.jsp?id=c_601812
http://www.has-sante.fr/portail/display.jsp?id=c_601750
2007
France
French
continuity of patient care
respiratory tract infections
penicillanic acid
cross infection
pseudomonas infections
pseudomonas aeruginosa
penicillanic acid
cystic fibrosis
beta-Lactamases
piperacillin
adult
child
infusions, intravenous
drug interactions
pregnancy
breast feeding
drug combinations
anti-infective agents, urinary
piperacillin and beta-lactamase inhibitor
guidelines for drug use
Piperacillin, Tazobactam Drug Combination
Tazobactam
---