Preferred Label : Progranulins;
MeSH definition : A cysteine-rich, precursor glycoprotein, encoded by the granulin gene (GRN). It contains
granulin-repeats separated by linker sequences that are cleaved by a variety of proteases
to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed
of a half granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS
are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide.
Progranulin has growth-factor like effects and is expressed over a broad range of
tissues. Under-expression of progranulin is linked to neurodegenerative diseases including
FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression
is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.; Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain
granulin-repeats separated by linker sequences that are cleaved by a variety of proteases
to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed
of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS
are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide.
Progranulin has growth-factor like effects and is expressed over a broad range of
tissues. Under-expression of progranulin is linked to neurodegenerative diseases including
FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression
is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.;
MeSH synonym : Proepithelin; Granulin Precursor; Granulin Precursor Protein; PC Cell-Derived Growth Factor; PC Cell Derived Growth Factor; Acrogranin; Progranulin;
MeSH Related Number : 134710-81-9;
Wikipedia link : https://en.wikipedia.org/wiki/Progranulin;
Origin ID : D000077153;
UMLS CUI : C0168913;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- MeSH indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A cysteine-rich, precursor glycoprotein, encoded by the granulin gene (GRN). It contains
granulin-repeats separated by linker sequences that are cleaved by a variety of proteases
to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed
of a half granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS
are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide.
Progranulin has growth-factor like effects and is expressed over a broad range of
tissues. Under-expression of progranulin is linked to neurodegenerative diseases including
FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression
is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain
granulin-repeats separated by linker sequences that are cleaved by a variety of proteases
to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed
of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS
are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide.
Progranulin has growth-factor like effects and is expressed over a broad range of
tissues. Under-expression of progranulin is linked to neurodegenerative diseases including
FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression
is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
