MeSH definition : An intracellular signaling and tumor suppressor protein that forms a complex with
TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively
regulate MTORC1 signaling and affect cell growth and proliferation. Structurally,
it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation
sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil
domain and ezrin-radixin moesin (ERM) domain. Mutations in the TSC1 gene are associated
with TUBEROUS SCLEROSIS.; An intracellular signaling and tumor suppressor protein that forms a complex with
TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively
regulate MTORC1 signaling and affect cell growth and proliferation. Structurally,
it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation
sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil
domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated
with TUBEROUS SCLEROSIS.;
MeSH synonym : Hamartin;
Wikipedia link : https://en.wikipedia.org/wiki/Hamartin;
An intracellular signaling and tumor suppressor protein that forms a complex with
TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively
regulate MTORC1 signaling and affect cell growth and proliferation. Structurally,
it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation
sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil
domain and ezrin-radixin moesin (ERM) domain. Mutations in the TSC1 gene are associated
with TUBEROUS SCLEROSIS. An intracellular signaling and tumor suppressor protein that forms a complex with
TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively
regulate MTORC1 signaling and affect cell growth and proliferation. Structurally,
it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation
sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil
domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated
with TUBEROUS SCLEROSIS.