CCCTC-Binding Factor

Preferred Label : CCCTC-Binding Factor;

MeSH definition : A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.;

MeSH synonym : CCCTC Binding Factor; DNA-Binding Protein CTCF; CTCF, DNA-Binding Protein; DNA Binding Protein CTCF; CTCF Protein;

Details

Origin ID

D000076246;

UMLS CUI

C0669443;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CCCTC-binding factor [ORDO Gene]
- CCCTC-binding factor [HGNC gene]
- Ccctc-binding factor [OMIM gene]
- Transcriptional Repressor CTCF [NCIt concept]
- Transcriptional Repressor CTCFL [NCIt concept]
Record concept(s)
- CCCTC-binding factor [MeSH concept]
Related MeSH Supplementary Concept(s)
- CTCF protein, drosophila [MeSH Supplementary Concept]
- CTCF protein, human [MeSH Supplementary Concept]
- Ctcf protein, mouse [MeSH Supplementary Concept]
- Ctcf protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients