MeSH definition : A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity.
It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes
to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA
B; it also binds to and activates TRAF6. Chromosomal translocations involving the
MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1
gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.;
A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity.
It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes
to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA
B; it also binds to and activates TRAF6. Chromosomal translocations involving the
MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1
gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.