" /> Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - CISMeF





Preferred Label : Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein;

MeSH definition : A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.;

MeSH synonym : Mucosa Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; MALT-1 Protein; MALT 1 Protein; MALT1 Protein; Paracaspase; MALT1 Paracaspase; Paracaspase, MALT1;

Registry Number MeSH : EC 3.4.22.-;

Wikipedia link : https://en.wikipedia.org/wiki/Paracaspase;

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A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.

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30/06/2025


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