NADPH Oxidase 2

Preferred Label : NADPH Oxidase 2;

MeSH definition : An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H ) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.;

MeSH synonym : Oxidase 2, NADPH; Chronic Granulomatous Disease Protein; GP91-PHOX Protein; GP91 PHOX Protein; CYBB Protein; Cytochrome B-245 Beta Chain; Cytochrome B 245 Beta Chain; NOX2 Protein;

Registry Number MeSH : EC 1.6.3.-;

Details

Origin ID

D000074662;

UMLS CUI

C4319655;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Cytochrome B-245 Heavy Chain [NCIt concept]
- Cytochrome b(-245), beta subunit [OMIM gene]
- cytochrome b-245 beta chain [ORDO Gene]
- cytochrome b-245 beta chain [HGNC gene]
Record concept(s)
- NADPH Oxidase 2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYBB protein, human [MeSH Supplementary Concept]
- cybb protein, mouse [MeSH Supplementary Concept]
- cybb protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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