Thyroid Nuclear Factor 1

Preferred Label : Thyroid Nuclear Factor 1;

MeSH definition : A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.;

MeSH synonym : Thyroid Transcription Factor 1; TITF-1 Protein; TITF 1 Protein; Homeobox Protein Nkx-2.1; Homeobox Protein Nkx 2.1; Nkx-2.1, Homeobox Protein; NK2 Homeobox 1 Protein; TITF1 Protein; TTF-1 Thyroid Nuclear Factor; TTF 1 Thyroid Nuclear Factor; Thyroid-Specific Enhancer-Binding Protein; Enhancer-Binding Protein, Thyroid-Specific; Thyroid Specific Enhancer Binding Protein;

Details

Origin ID

D000074482;

UMLS CUI

C0084785;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- NK2 Homeobox 1 Measurement [NCIt concept]
- Nk2 homeobox 1 [OMIM gene]
- Thyroid Transcription Factor 1 [NCIt concept]
- Thyroid transcription factor 1 [LOINC component]
Record concept(s)
- thyroid nuclear factor 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- NKX2-1 protein, human [MeSH Supplementary Concept]
- Nkx2-1 protein, mouse [MeSH Supplementary Concept]
- Nkx2-1 protein, rat [MeSH Supplementary Concept]
- nkx2-1 protein, Xenopus [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Thyroid transcription factor 1 [LOINC component]

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