" /> Zinc Finger Protein Gli3 - CISMeF





Preferred Label : Zinc Finger Protein Gli3;

MeSH definition : A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.;

MeSH synonym : Glioma-Associated Oncogene Family Zinc Finger 3 Protein; Glioma Associated Oncogene Family Zinc Finger 3 Protein; GLI-Kruppel Family Member 3 Protein; GLI Kruppel Family Member 3 Protein;

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A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

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04/05/2025


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