ADAM17 Protein

Preferred Label : ADAM17 Protein;

MeSH definition : A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.;

MeSH synonym : TACE (Enzyme); TNF-alpha Converting Enzyme; TNF alpha Converting Enzyme; Tumor Necrosis Factor Alpha Convertase; ADAM-17; Tumor Necrosis Factor-alpha Converting Enzyme; Tumor Necrosis Factor alpha Converting Enzyme; TNF-alpha Convertase; Convertase, TNF-alpha; TNF alpha Convertase; CD156b Antigen; Antigen, CD156b; ADAM-17 Protein; ADAM 17 Protein; Disintegrin and Metalloproteinase Domain-Containing Protein 17; Disintegrin and Metalloproteinase Domain Containing Protein 17; TACA (Enzyme); Tumor Necrosis Factor-alpha Convertase;

Registry Number MeSH : EC 3.4.24.86;

Wikipedia link : https://en.wikipedia.org/wiki/Adam17 protein;

UNII : EC 3.4.24.86;

Details

Origin ID

D000072198;

UMLS CUI

C0529196;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- A disintegrin and metalloproteinase domain 17 [OMIM gene]
- ADAM metallopeptidase domain 17 [ORDO Gene]
- ADAM17 Gene [NCIt concept]
- ADAM17 wt Allele [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 17 [NCIt concept]
Record concept(s)
- ADAM17 Protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- ADAM17 protein, human [MeSH Supplementary Concept]
- Adam17 protein, mouse [MeSH Supplementary Concept]
- Adam17 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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