Prion Proteins

Preferred Label : Prion Proteins;

MeSH definition : Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.;

MeSH synonym : Prion Protein; CD230 Antigen; Antigen, CD230; PrP Proteins; Fatal Familial Insomnia Protein; Major Prion Protein; Prion Protein, Major; Creutzfeldt-Jakob Disease Protein; Creutzfeldt Jakob Disease Protein;

DeCS synonym : Alternative Prion Protein;

Related MeSH term : Prion Protein, Alternative; AltPrP;

Details

Origin ID

D000072002;

UMLS CUI

C4082486;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Major Prion Protein [NCIt concept]
- PRNP wt Allele [NCIt concept]
- Prion (organism) [SNOMED CT concept]
- Prion protein [OMIM gene]
- prion protein [ORDO Gene]
- prion protein (Kanno blood group) [HGNC gene]
Currated CISMeF NLP mapping
- Prion protein [LOINC component]
Record concept(s)
- Alternative Prion Protein [MeSH concept]
- Prion Proteins [MeSH concept]
Related MeSH Supplementary Concept(s)
- PRNP protein, human [MeSH Supplementary Concept]
- prnp protein, leucyl(101), mouse [MeSH Supplementary Concept]
- prnp protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- Prion protein [LOINC component]

Keyword's position in hierarchy(ies) :

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