Major Prion Protein

Preferred Label : Major Prion Protein;

NCIt synonyms : CD230 antigen; PrP; PrP33-35C; PrP27-30; ASCR; PRNP;

NCIt definition : Major prion protein (253 aa, 28 kDa) is encoded by the human PRNP gene. This protein is bound to the membrane by a glycosylphosphatidylinositol-anchor and it plays a role in the pathology and transmission of human prion diseases.;

NCIt note : The non-pathological function of major prion protein is unknown.;

Details

Origin ID

C71456;

UMLS CUI

C2346932;

Currated CISMeF NLP mapping
- (ctm)PrP [MeSH concept]
- (ctm)PrP [MeSH Supplementary Concept]
- PrP (CJD) [MeSH concept]
- PrP (GSS) [MeSH concept]
OMIM relation
- Prion protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- PRNP Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Prion Disease Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Creutzfeldt-Jakob Disease [NCIt concept]

Keyword's position in hierarchy(ies) :

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