Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Preferred Label : Alpha-Ketoglutarate-Dependent Dioxygenase FTO;

MeSH definition : A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.;

MeSH synonym : Alpha Ketoglutarate Dependent Dioxygenase FTO; FTO, Alpha-Ketoglutarate-Dependent Dioxygenase; Fat Mass and Obesity Associated (FTO) Protein; Alpha-Ketoglutarate-Dependent Dioxygenase; Alpha Ketoglutarate Dependent Dioxygenase; Dioxygenase, Alpha-Ketoglutarate-Dependent; Fat Mass and Obesity Associated Protein; AlkB Homolog 9 Protein;

Registry Number MeSH : EC 1.14.11.33;

UNII : EC 1.14.11.33;

Details

Origin ID

D000071516;

UMLS CUI

C4255071;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO [NCIt concept]
- DNA-N1-methyladenine dioxygenase activity [GO term]
- FTO alpha-ketoglutarate dependent dioxygenase [ORDO Gene]
- FTO alpha-ketoglutarate dependent dioxygenase [HGNC gene]
- Fto alpha-ketoglutarate-dependent dioxygenase [OMIM gene]
Record concept(s)
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO [MeSH concept]
Related MeSH Supplementary Concept(s)
- FTO protein, human [MeSH Supplementary Concept]
- FTO protein, mouse [MeSH Supplementary Concept]
- FTO protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

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