" /> N-Myc Proto-Oncogene Protein - CISMeF





Preferred Label : N-Myc Proto-Oncogene Protein;

MeSH definition : A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.;

MeSH synonym : N Myc Proto Oncogene Protein; Proto-Oncogene Protein, N-Myc; BHLHE37 Protein; NMYC Protein; Class E Basic Helix-Loop-Helix Protein 37; Class E Basic Helix Loop Helix Protein 37; N-Myc Protein; N Myc Protein; MYCN Protein;

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A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

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29/07/2025


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