" /> NLR Family, Pyrin Domain-Containing 3 Protein - CISMeF





Preferred Label : NLR Family, Pyrin Domain-Containing 3 Protein;

MeSH definition : An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.;

MeSH synonym : NLR Family, Pyrin Domain Containing 3 Protein; Cold Autoinflammatory Syndrome 1 Protein; NACHT, LRR and PYD Domains-Containing Protein 3; NACHT, LRR and PYD Domains Containing Protein 3; NLRP3 Protein;

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An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

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02/05/2025


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