MeSH definition : A tripartite motif protein that consists of an N-terminal pyrin domain, a central
coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate
homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It
is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton
in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly
of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions
in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are
associated with FAMILIAL MEDITERRANEAN FEVER.;
A tripartite motif protein that consists of an N-terminal pyrin domain, a central
coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate
homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It
is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton
in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly
of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions
in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are
associated with FAMILIAL MEDITERRANEAN FEVER.