MeSH definition : A protein interaction domain of the death domain superfamily. It is characterized
by a 6-helix bundle similar to those that occur in DEATH DOMAIN RECEPTORS. Pyrin domains
are present in a variety of proteins, especially those that function in INFLAMMASOMES;
AUTOPHAGY; and APOPTOSIS. They form homodimers or heterodimers with death domain proteins
to facilitate the assembly of signaling complexes.;
A protein interaction domain of the death domain superfamily. It is characterized
by a 6-helix bundle similar to those that occur in DEATH DOMAIN RECEPTORS. Pyrin domains
are present in a variety of proteins, especially those that function in INFLAMMASOMES;
AUTOPHAGY; and APOPTOSIS. They form homodimers or heterodimers with death domain proteins
to facilitate the assembly of signaling complexes.