Autophagy-Related Protein-1 Homolog

Preferred Label : Autophagy-Related Protein-1 Homolog;

MeSH definition : A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.;

MeSH synonym : Autophagy Related Protein 1 Homolog; Serine-Threonine Protein Kinase ULK1; Serine Threonine Protein Kinase ULK1; Unc-51 Like Autophagy Activating Kinase 1; Unc 51 Like Autophagy Activating Kinase 1; ULK1 Protein; Unc-51-Like Kinase 1; Unc 51 Like Kinase 1;

Registry Number MeSH : EC 2.7.11.1;

UNII : EC 2.7.11.1;

Details

Origin ID

D000071189;

UMLS CUI

C4255263;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Serine/Threonine-Protein Kinase ULK1 [NCIt concept]
- Unc51-like autophagy-activating kinase 1 [OMIM gene]
- unc-51 like autophagy activating kinase 1 [HGNC gene]
Record concept(s)
- Autophagy-Related Protein-1 Homolog [MeSH concept]
Related MeSH Supplementary Concept(s)
- Atg1 protein, drosophila [MeSH Supplementary Concept]
- ULK1 protein, human [MeSH Supplementary Concept]
- ULK1 protein, mouse [MeSH Supplementary Concept]
- ULK1 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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