Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - CISMeF
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2MeSH Descriptor
Preferred Label : Leucine-Rich Repeat Serine-Threonine Protein Kinase-2;
MeSH definition : A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich
repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase
domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and
the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology
in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES.
Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON
DISEASE (PARK8).;
A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich
repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase
domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and
the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology
in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES.
Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON
DISEASE (PARK8).