Preferred Label : Lubiprostone;
MeSH definition : Member of a bicyclic fatty acid class of compounds derived from PROSTAGLANDIN E1 involved
in chloride channel gating.;
MeSH synonym : Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11alpha)-;
MeSH Hyperonym : amitiza;
MeSH hyponym : SPI 0211; RU 0211; 0211, RU; RU0211; RU-0211; 0211, SPI; SPI0211; SPI-0211;
MeSH CAS label : 7-((1R,4R,6R,9R)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo(4.3.0)non-9-yl)heptanoic
acid;
Wikipedia link : https://en.wikipedia.org/wiki/Lubiprostone;
Is substance : O;
UNII : 7662KG2R6K;
Origin ID : D000068238;
UMLS CUI : C1684405;
ATC code(s)
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
CISMeF manual mappings
Currated CISMeF NLP mapping
Pharmacological action(s)
Record concept(s)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
Member of a bicyclic fatty acid class of compounds derived from PROSTAGLANDIN E1 involved
in chloride channel gating.
Summary Basis of Decision (SBD) for Amitiza
https://hpr-rps.hres.ca/reg-content/sommaire-motif-decision-detailTwo.php?lang=fr&linkID=SBD00337
2016
false
Canada
French
English
summary of product characteristics
chronic idiopathic constipation
Chloride Channel Agonists
Chloride Channel Agonists
drug approval
canada
administration, oral
treatment outcome
Product containing precisely lubiprostone 24 microgram/1 each conventional release
oral capsule (clinical drug)
Lubiprostone
Lubiprostone
constipation
chronic disease
adult
clinical trials as topic
aged
lubiprostone
---
https://www.cadth.ca/sites/default/files/pdf/E0020_lubiprostone_edrug_f.pdf
2007
false
Canada
French
Lubiprostone
Lubiprostone
constipation
chronic disease
adult
clinical trials as topic
aged
lubiprostone
drug evaluation
---