Lubiprostone - CISMeF

Preferred Label : Lubiprostone;

NCIt definition : A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium. This produces an efflux of chloride ions, thereby drawing water into the gastrointestinal lumen. The resulting increased amounts of intestinal fluid soften the stool, increase motility, and improve bowel movements.;

UNII : 7662KG2R6K;

InChIKey : WGFOBBZOWHGYQH-MXHNKVEKSA-N;

CAS number : 333963-40-9;

Drug name : Amitiza;

Chemical formula : C20H32F2O5;

Details

Origin ID

C66040;

UMLS CUI

C1684405;

Automatic exact mappings (from CISMeF team)
- Lubiprostone [ICD-11 Extension code]
CISMeF manual mappings
- Lubiprostone [MeSH Descriptor]
Currated CISMeF NLP mapping
- Lubiprostone (substance) [SNOMED CT concept]
- lubiprostone [MeSH concept]
See also inter- (CISMeF)
- Product containing lubiprostone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lubiprostone [MeSH Descriptor]
- Lubiprostone (substance) [SNOMED CT concept]
- Product containing lubiprostone (medicinal product) [SNOMED CT concept]
- lubiprostone [ATC Code]
- lubiprostone [MeSH concept]
Validated automatic mappings to BTNT
- lubiprostone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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