Testicular germ cell tumor

Preferred Label : Testicular germ cell tumor;

Symbol : TGCT;

CISMeF acronym : MGCT; TGCT;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Male germ cell tumor; MGCT;

Included titles and symbols : Seminoma; Nonseminomatous germ cell tumors; Teratoma, testicular; Embryonal cell carcinoma; Endodermal sinus tumor; Spermatocytic seminoma;

Description : Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold. This familial relative risk is much higher than that for most other types of cancer (summary by Rapley et al., 2000). - Genetic Heterogeneity of Testicular Germ Cell Tumors A locus for testicular germ cell tumors (TGCT1; 300228) has been identified on chromosome Xq27.;

Inheritance : Somatic mutation;

Neoplasia : Male germ cell tumors (GCT), 2 subtypes -; Seminoma; Nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor);

Laboratory abnormalities : Isochromosome 12p (i(12p)); Elevated hCG or AFP or both (embryonal carcinoma); Elevated AFP (endodermal sinus tumor); Elevated hCG (choriocarcinoma); Azoospermia/oligospermia (present at diagnosis);

Prefixed ID : #273300;

Details

Origin ID

273300;

UMLS CUI

C1336708;

Automatic exact mappings (from CISMeF team)
- Childhood Testicular Germ Cell Tumor [NCIt concept]
- Endodermal sinus tumor [ICD-9 code]
- Endodermal sinus tumor [PASCAL descriptor]
- Endodermal sinus tumor (morphologic abnormality) [SNOMED CT concept]
- Endodermal sinus tumour, unspecified site, male [ICD-11 More detail]
- Extragonadal teratoma [ORDO Disease]
- Germ cell tumor, nonseminomatous [ICD-O code]
- Germ cell tumor, nonseminomatous (morphologic abnormality) [SNOMED CT concept]
- Malignant teratoma of testis [ICD-11 Subcategory]
- Nongerminomatous Germ Cell Tumor [NCIt concept]
- Nonseminomatous germ cell tumor [MeSH concept]
- Spermatocytic seminoma [ICD-O code]
- Spermatocytic seminoma [ICD-9 code]
- Spermatocytic seminoma [MedDRA Preferred Term]
- Spermatocytic seminoma [ORDO Disease]
- Spermatocytic seminoma [ICD-11 Extension code]
- Spermatocytic seminoma (morphologic abnormality) [SNOMED CT concept]
- Tenosynovial giant cell tumor [ORDO Disease]
- Testicular Spermatocytic Tumor [NCIt concept]
- Testicular seminomatous germ cell tumor [ORDO Disease]
- Yolk Sac Tumor [NCIt concept]
- Yolk sac tumor [ORDO Disease]
- embryonal carcinoma stem cells [MeSH Descriptor]
- embryonal cell carcinoma [Radlex concept]
- endodermal sinus tumor [MeSH Descriptor]
- endodermal sinus tumor [MeSH concept]
- endodermal sinus tumor [DO Concept]
- endodermal sinus tumor [SNOMED Notion]
- male germ cell tumor [MeSH concept]
- male germ cell tumor [MeSH Supplementary Concept]
- non-seminomatous germ cell tumor [Radlex concept]
- nonseminomatous germ cell tumor [MeSH Supplementary Concept]
- spermatocytic seminoma [Radlex concept]
- spermatocytic seminoma [SNOMED Notion]
- spermatocytoma [DO Concept]
- testicular cancer [MedlinePlus Topic]
Currated CISMeF NLP mapping
- Germ cell tumor of testis [ORDO Disease]
- Germ cell tumor of testis (disorder) [SNOMED CT concept]
- SEMINOMA [WHO-ART Preferred Term]
- Seminoma [MedDRA Preferred Term]
- Seminoma [PASCAL descriptor]
- Seminoma [NCIt concept]
- Seminoma (disorder) [SNOMED CT concept]
- Seminoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Testicular Germ Cell Tumor [NCIt concept]
- Testicular Teratoma [NCIt concept]
- Testicular germ cell tumor [PASCAL descriptor]
- Testicular germ cell tumor [MedDRA LLT]
- Testicular germ cell tumour [MedDRA Preferred Term]
- Testicular teratoma [HPO term]
- Testicular teratoma [ORDO Disease]
- seminoma [Disease (Nov.)]
- seminoma [Radlex concept]
- seminoma [MeSH concept]
- seminoma [MeSH Descriptor]
- seminoma [DO Concept]
- teratoma, testicular [MeSH concept]
- teratoma, testicular [MeSH Supplementary Concept]
- testicular germ cell cancer [DO Concept]
- testicular germ cell neoplasm [Disease (Nov.)]
- testicular germ cell tumor [MeSH concept]
- testicular germ cell tumor [MeSH Supplementary Concept]
- testicular teratoma [Disease (Nov.)]
DO Cross reference
- testicular germ cell cancer [DO Concept]
Genes related to phenotype
- Bcl10 immune signaling adaptor [OMIM gene]
- Fibroblast growth factor receptor 3 [OMIM gene]
- Kit protooncogene, receptor tyrosine kinase [OMIM gene]
- Serine/threonine protein kinase 11 [OMIM gene]
HPO term(s)
- Azoospermia [HPO term]
- Choriocarcinoma [HPO term]
- Elevated alpha-fetoprotein [HPO term]
- Embryonal neoplasm [HPO term]
- Isolated cases [HPO term]
- Somatic mutation [HPO term]
- Sporadic [HPO term]
- Teratoma [HPO term]
ORDO concept(s)
- Germ cell tumor of testis [ORDO Disease]
- Non-seminomatous germ cell tumor of testis [ORDO Disease]
- Spermatocytic seminoma [ORDO Disease]
- Testicular seminomatous germ cell tumor [ORDO Disease]
- Testicular teratoma [ORDO Disease]
- Yolk sac tumor [ORDO Disease]
See also inter- (CISMeF)
- Teratoma of testis (disorder) [SNOMED CT concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Germ cell tumor of testis [ORDO Disease]
- Germ cell tumor of testis (disorder) [SNOMED CT concept]
- Testicular Germ Cell Tumor [NCIt concept]
- Testicular germ cell tumor [MedDRA LLT]
- Testicular germ cell tumour [MedDRA Preferred Term]
- testicular germ cell cancer [DO Concept]
- testicular germ cell neoplasm [Disease (Nov.)]
- testicular germ cell tumor [MeSH Supplementary Concept]
- testicular germ cell tumor [MeSH concept]
Validated automatic mappings to BTNT
- spermatocytic seminoma [Disease (Nov.)]

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