Preferred Label : Leukemia, chronic lymphocytic;
Symbol : CLL;
CISMeF acronym : CLL;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Leukemia, chronic lymphatic;
Description : Chronic lymphocytic leukemia (CLL) is a common neoplasia of B lymphocytes in which
these cells progressively accumulate in the bone marrow, blood, and lymphoid tissues.
The clinical evolution of the disorder is heterogeneous, with some patients having
indolent disease and others having aggressive disease and short survival (summary
by Quesada et al., 2012). - Genetic Heterogeneity of Susceptibility to Chronic Lymphocytic
Leukemia Susceptibility loci have been mapped to chromosomes 11p11 (CLLS1; 609630)
and 13q14 (CLLS2; 109543) by genomewide linkage analysis and translocation studies,
respectively. Susceptibility mapping to chromosome 9q34 (CLLS3; 612557) is associated
with downregulation of the;
Inheritance : Autosomal dominant; Somatic mutation;
Laboratory abnormalities : Recurring t(11,14) and t(14,19)(q32,q13.1) translocations;
Prefixed ID : #151400;
Origin ID : 151400;
UMLS CUI : C0023434;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- HPO term(s)
- Narrower ORDO disease(s)
- ORDO concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
