ICD-11 code : 2A82.00;
Preferred Label : Chronic lymphocytic leukaemia of B-cell type;
ICD-11 definition : Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm composed
of monomorphic small, round to slightly irregular B lymphocytes in the peripheral
blood (PB), bone marrow (BM), spleen and lymph nodes, admixed with prolymphocytes
and paraimmunoblasts forming proliferation centres in tissue infiltrates. The CLL/SLL
cells usually coexpress CD5 and CD23. In the absence of extramedullary tissue involvement,
there must be 5x109/L monoclonal lymphocytes with a CLL phenotype in the PB. The
International Workshop on Chronic Lymphocytic Leukemia (IWCLL) report requires that
the lymphocytosis be present for at least 3 months and also allows for the diagnosis
of CLL to be made with lower lymphocyte counts in patients with cytopenias or disease-related
symptoms. Whether patients who would have fulfilled the criteria in the past for CLL
but who fulfill the criteria only for monoclonal B lymphocytosis (MBL) are better
considered to have low stage CLL or MBL remains to be determined. Some may prefer
to still consider many of these cases more like CLL. The term SLL is used for non-leukaemic
cases with the tissue morphology and immunophenotype of CLL. The IWCLL definition
of SLL requires lymphadenopathy, no cytopenias due to BM infiltration by CLL/SLL and
5x109/L PB B-cells.;
ICD-11 synonym : Lymphoplasmacytic leukaemia; chronic lymphatic leukaemia; chronic lymphoid leukaemia; chronic lymph leukaemia;
ICD-11 inclusion : Lymphoplasmacytic leukaemia;
Origin ID : 1726842351;
Automatic exact mappings (from CISMeF team)
- ICD-10 Mapping
Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm composed
of monomorphic small, round to slightly irregular B lymphocytes in the peripheral
blood (PB), bone marrow (BM), spleen and lymph nodes, admixed with prolymphocytes
and paraimmunoblasts forming proliferation centres in tissue infiltrates. The CLL/SLL
cells usually coexpress CD5 and CD23. In the absence of extramedullary tissue involvement,
there must be 5x109/L monoclonal lymphocytes with a CLL phenotype in the PB. The
International Workshop on Chronic Lymphocytic Leukemia (IWCLL) report requires that
the lymphocytosis be present for at least 3 months and also allows for the diagnosis
of CLL to be made with lower lymphocyte counts in patients with cytopenias or disease-related
symptoms. Whether patients who would have fulfilled the criteria in the past for CLL
but who fulfill the criteria only for monoclonal B lymphocytosis (MBL) are better
considered to have low stage CLL or MBL remains to be determined. Some may prefer
to still consider many of these cases more like CLL. The term SLL is used for non-leukaemic
cases with the tissue morphology and immunophenotype of CLL. The IWCLL definition
of SLL requires lymphadenopathy, no cytopenias due to BM infiltration by CLL/SLL and
5x109/L PB B-cells.
