Chronic Lymphocytic Leukemia

Preferred Label : Chronic Lymphocytic Leukemia;

NCIt synonyms : B Cell Chronic Lymphocytic Leukemia; B-Cell Chronic Lymphocytic Leukemia; Chronic B-Cell Lymphocytic Leukemia; Hematopoeitic - Chronic Lymphocytic Leukemia (CLL); B Cell CLL; B-Cell Lymphocytic Leukemia; B Cell Lymphocytic Leukemia; B-Cell Chronic Lymphoid Leukemia; B-Cell CLL; BCLL;

NCIt related terms : Chronic Lymphocytic Leukemia (CLL); Chronic lymphatic leukemia; CLL; Chronic lymphocytic leukemia, NOS;

NCIt definition : The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001);

Alternative definition : NCI-GLOSS: An indolent (slow-growing) cancer in which too many immature lymphocytes (white blood cells) are found mostly in the blood and bone marrow. Sometimes, in later stages of the disease, cancer cells are found in the lymph nodes and the disease is called small lymphocytic lymphoma.;

Neoplastic status : Malignant;

Codes from synonyms : CDR0000346545; CDR0000044846; 10008960;

Details

Origin ID

C3163;

UMLS CUI

C0023434;

Automatic exact mappings (from CISMeF team)
- B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (morphologic abnormality) [SNOMED CT concept]
- Chronic lymphocytic leukaemia of B-cell type [ICD-11 Sub-sub category]
- Chronic lymphocytic leukaemia or small lymphocytic lymphoma [ICD-11 Subcategory]
- Chronic lymphocytic leukemia [LOINC component]
- Chronic lymphoid leukemia, disease (disorder) [SNOMED CT concept]
- chronic leukemia [DO Concept]
- chronic lymphocytic leukemia [DO Concept]
- chronic lymphocytic leukemia [MedlinePlus Topic]
- leukemia, B-Cell [MeSH concept]
- leukemia, b-cell [MeSH Descriptor]
Currated CISMeF NLP mapping
- B-cell chronic lymphocytic leukaemia [MedDRA LLT]
- B-cell chronic lymphocytic leukemia [ORDO Disease]
- B-cell chronic lymphocytic leukemia [MedDRA LLT]
- B-cell chronic lymphocytic leukemia (disorder) [SNOMED CT concept]
- CLL [MedDRA LLT]
- Chronic lymphatic leukaemia [MedDRA LLT]
- Chronic lymphatic leukemia [HPO term]
- Chronic lymphatic leukemia [MedDRA LLT]
- Chronic lymphocytic leukaemia [ICD-10 Sub-category (who)]
- Chronic lymphocytic leukaemia [MedDRA Preferred Term]
- Chronic lymphocytic leukaemia NOS [MedDRA LLT]
- Chronic lymphocytic leukemia [PASCAL descriptor]
- Chronic lymphocytic leukemia [MedDRA LLT]
- Chronic lymphocytic leukemia of B-cell type [ICD-10 Sub-category]
- Chronic lymphoid leukaemia [MedDRA LLT]
- Chronic lymphoid leukemia [ICD-9 code]
- Chronic lymphoid leukemia [MedDRA LLT]
- Leukaemia lymphocytic chronic [MedDRA LLT]
- Leukaemias chronic lymphocytic [MedDRA High Level Term]
- Leukemia lymphocytic chronic [MedDRA LLT]
- Leukemia, chronic lymphocytic [OMIM Phenotype]
- Lymphoid leukaemia, chronic [MedDRA LLT]
- Lymphoid leukemia, chronic [MedDRA LLT]
- Lymphoid leukemia, chronic [ICD-9 code]
- chronic lymphocytic leukemia [Blood Transfusion thesaurus concept]
- leukemia, lymphocytic, chronic, B-Cell [MeSH Descriptor]
- leukemia, lymphocytic, chronic, B-Cell [MeSH concept]
DO Cross reference
- chronic lymphocytic leukemia [DO Concept]
Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Fatigue [NCIt concept]
- Lymphadenopathy [NCIt concept]
False automatic mappings
- Chronic lymphocytic leukaemia (in remission) [MedDRA Preferred Term]
- Chronic lymphocytic leukemia (in remission) [MedDRA LLT]
- Leukemia, chronic lymphocytic, susceptibility to, 2 [OMIM Phenotype]
- chronic lymphocytic leukemia [SNOMED Notion]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- B-cell chronic lymphocytic leukaemia [MedDRA LLT]
- B-cell chronic lymphocytic leukemia [MedDRA LLT]
- B-cell chronic lymphocytic leukemia (disorder) [SNOMED CT concept]
- B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (morphologic abnormality) [SNOMED CT concept]
- CLL [MedDRA LLT]
- Chronic lymphatic leukaemia [MedDRA LLT]
- Chronic lymphatic leukemia [MedDRA LLT]
- Chronic lymphatic leukemia [HPO term]
- Chronic lymphocytic leukaemia [MedDRA Preferred Term]
- Chronic lymphocytic leukaemia [ICD-10 Sub-category (who)]
- Chronic lymphocytic leukaemia NOS [MedDRA LLT]
- Chronic lymphocytic leukemia [MedDRA LLT]
- Chronic lymphocytic leukemia [PASCAL descriptor]
- Chronic lymphocytic leukemia [LOINC component]
- Chronic lymphocytic leukemia of B-cell type [ICD-10 Sub-category]
- Chronic lymphoid leukaemia [MedDRA LLT]
- Chronic lymphoid leukemia [MedDRA LLT]
- Chronic lymphoid leukemia, disease (disorder) [SNOMED CT concept]
- Leukaemia lymphocytic chronic [MedDRA LLT]
- Leukaemias chronic lymphocytic [MedDRA High Level Term]
- Leukemia lymphocytic chronic [MedDRA LLT]
- Leukemia, chronic lymphocytic [OMIM Phenotype]
- Lymphoid leukaemia, chronic [MedDRA LLT]
- Lymphoid leukemia, chronic [ICD-9 code]
- Lymphoid leukemia, chronic [MedDRA LLT]
- chronic lymphocytic leukemia [MedlinePlus Topic]
- chronic lymphocytic leukemia [DO Concept]
- chronic lymphocytic leukemia [SNOMED Notion]
- leukemia, lymphocytic, chronic, B-Cell [MeSH Descriptor]
- leukemia, lymphocytic, chronic, B-Cell [MeSH concept]
Validated automatic mappings to BTNT
- B cell chronic lymphocytic leukemia [Disease (Nov.)]
associated_with_malfunction_of_gene_product
- B-Cell Lymphoma Protein 3 [NCIt concept]
- Protein BTG2 [NCIt concept]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Portfolio Management Subtype Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI CTEP SDC Chronic Lymphoid Leukemia Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Acute Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Leukemic Small Lymphocyte with Clumped Chromatin [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Small Lymphocyte with Clumped Chromatin [NCIt concept]
disease_has_accepted_treatment_with_regimen
- CVP Regimen [NCIt concept]
- Chlorambucil/Prednisone Regimen [NCIt concept]
- Cyclophosphamide/Fludarabine/Rituximab and Hyaluronidase Regimen [NCIt concept]
- FC Regimen [NCIt concept]
- FCR Regimen [NCIt concept]
- FP Regimen [NCIt concept]
- FR Regimen [NCIt concept]
disease_has_associated_disease
- Mu Heavy Chain Disease [NCIt concept]
- Richter Syndrome [NCIt concept]
disease_has_associated_gene
- BTG2 Gene [NCIt concept]
- BTG2 wt Allele [NCIt concept]
- DLEU1 Gene [NCIt concept]
- DLEU1 wt Allele [NCIt concept]
- DLEU2 Gene [NCIt concept]
- DLEU2 wt Allele [NCIt concept]
- MCL1 Gene [NCIt concept]
- MCL1 wt Allele [NCIt concept]
- MIR106B Gene [NCIt concept]
- MIR106B wt Allele [NCIt concept]
- MIR143 Gene [NCIt concept]
- MIR143 wt Allele [NCIt concept]
- MIR145 Gene [NCIt concept]
- MIR145 wt Allele [NCIt concept]
- MIR15A Gene [NCIt concept]
- MIR15A wt Allele [NCIt concept]
- MIR15B Gene [NCIt concept]
- MIR15B wt Allele [NCIt concept]
- MIR16-2 Gene [NCIt concept]
- MIR16-2 wt Allele [NCIt concept]
- MIR181B1 Gene [NCIt concept]
- MIR181B1 wt Allele [NCIt concept]
- MIR181B2 Gene [NCIt concept]
- MIR181B2 wt Allele [NCIt concept]
- MIR27B Gene [NCIt concept]
- MIR27B wt Allele [NCIt concept]
- MIR29B1 Gene [NCIt concept]
- MIR29B1 wt Allele [NCIt concept]
- MIR29B2 Gene [NCIt concept]
- MIR29B2 wt Allele [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]

Keyword's position in hierarchy(ies) :

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